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三尖杉宁碱

三尖杉宁碱用途

Cephalomannine是紫杉醇衍生物,具有抗肿瘤活性。

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三尖杉宁碱名称

[ CAS 号 ]:
71610-00-9

[ 中文名 ]:
三尖杉宁碱

[ 英文名 ]:
Cephalomannine

[中文别名 ]:

紫杉醇相关物质A

[英文别名 ]:

Paclitaxel Related CoMpound A
chephalomannine
caphalomannine
TAXOL B
CEPHALOMANNINE (TAXOL B)
CEPHALOMANNINE(P)

三尖杉宁碱生物活性

[ 描述 ]:

Cephalomannine是紫杉醇衍生物,具有抗肿瘤活性。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白

信号通路 >> 细胞骨架 >> 微管/微管蛋白

天然产物 >> 萜类化合物和糖苷

研究领域 >> 癌症

[参考文献]

[1]. T. Grobosch, B. Schwarze, D. Stoecklein et al. Fatal poisoning with Taxus baccata. Quantification of Paclitaxel (taxol A), 10-Deacetyltaxol, Baccatin III, 10-Deacetylbaccatin III, Cephalomannine (taxol B), and 3,5-Dimethoxyphenol in Body Fluids by Liquid

[2]. Jing Zhang et al., Simultaneous Determination of 10-Deacetylbaccatin，Cephalomannine and Taxol in Different Parts of Taxus Media with Different Growth Years by UPLC. Applied Mechanics and Materials. 2011, 108, 326.

[3]. Chang Z, Guo N, Liu T, et al. Distribution and variation of paclitaxel and cephalomannine contents in wild Taxus cuspidata. Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(3):294-8.

[4]. R Matesanz, J Rodríguez-Salarichs, B Pera, et al. Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes. Biophysical Journal, 2011,101(12): 2970-2980.

[5]. Elena Riva, Martin Mattarella, Stella Borrelli, et al. Preparation of Fluorescent Tubulin Binders. ChemPlusChem. Early View (Online Version of Record published before inclusion in an issue)

[相关活性小分子]

三尖杉宁碱物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
929.5±65.0 °C at 760 mmHg

[ 熔点 ]:
139-141ºC

[ 分子式 ]:
C₄₅H₅₃NO₁₄

[ 分子量 ]:
831.901

[ 闪点 ]:
516.0±34.3 °C

[ 精确质量 ]:
831.346619

[ PSA ]:
221.29000

[ LogP ]:
6.59

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
DMSO: 14 mg/mL, soluble

三尖杉宁碱MSDS

三尖杉宁碱安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
37/38-41

[ 安全声明 (欧洲) ]:
26-39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2932999022

三尖杉宁碱合成路线

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三尖杉宁碱海关

[ 海关编码 ]: 2932999022

三尖杉宁碱文献

Determination of paclitaxel and related taxanes in bulk drug and injectable dosage forms by reversed phase liquid chromatography.

Anal. Chem. 69(11) , 2008-16, (1997)

Baseline separation of 15 taxanes including paclitaxel (Taxol) was achieved on pentafluorophenyl (PFP) HPLC columns. Methods using aqueous acetonitrile gradients on each of two commercial PFP columns ...

Determination of cephalomannine in rat plasma by gradient elution UPLC-MS/MS method.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 963 , 70-4, (2014)

A rapid, sensitive and selective ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of ce...

Microbial transformation of cephalomannine by Luteibacter sp.

J. Nat. Prod. 70(12) , 1846-9, (2007)

Luteibacter sp., a new bacterium isolated from the soil around a Taxus cuspidata Sieb. et Zucc plant, was studied for its capability to metabolize cephalomannine (1). After preparative fermentation, e...

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