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盐酸阿莫洛芬

盐酸阿莫洛芬用途

Amorolfine盐酸盐是抗真菌剂。

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盐酸阿莫洛芬名称

[ CAS 号 ]:
78613-38-4

[ 中文名 ]:
盐酸阿莫洛芬

[ 英文名 ]:
Amorolfine hydrochloride

[中文别名 ]:

[英文别名 ]:

Loceryl
Locetar
Amorolfine Hydrochloride
MFCD00903738
Curanail
Amorolfine HCl
Odenil

盐酸阿莫洛芬生物活性

[ 描述 ]:

Amorolfine盐酸盐是抗真菌剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[参考文献]

[1]. Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7.

[2]. Richardson, M.D., G.S. Shankland, and C.A. Gray, Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Mycoses, 1989. 32(5): p. 245-9.

[相关活性小分子]

盐酸阿莫洛芬物理化学性质

[ 密度 ]:
1.234

[ 沸点 ]:
78-82°C (9 Torr)

[ 分子式 ]:
C₂₁H₃₆ClNO

[ 分子量 ]:
353.970

[ 精确质量 ]:
353.248535

[ PSA ]:
12.47000

[ LogP ]:
5.40190

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
room temp

[ 水溶解性 ]:
可溶于：甲醇

盐酸阿莫洛芬MSDS

详细MSDS(安全技术说明书)

盐酸阿莫洛芬安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H411

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ 海关编码 ]:
29411010

盐酸阿莫洛芬海关

[ 海关编码 ]: 29411010

盐酸阿莫洛芬文献

The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment.

Antimicrob. Agents Chemother. 58(7) , 3837-42, (2014)

Onychomycosis is a common fungal nail disease that is difficult to treat topically due to the deep location of the infection under the densely keratinized nail plate. Keratin affinity of topical drugs...

Characterization of Antifungal Activity and Nail Penetration of ME1111, a New Antifungal Agent for Topical Treatment of Onychomycosis.

Antimicrob. Agents Chemother. 60 , 1035-9, (2016)

Fungal nail infection (onychomycosis) is a prevalent disease in many areas of the world, with a high incidence approaching 23%. Available antifungals to treat the disease suffer from a number of disad...

Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis.

Antimicrob. Agents Chemother. 60 , 873-80, (2016)

Despite the existing treatment options for onychomycosis, there remains a strong demand for potent topical medications. ME1111 is a novel antifungal agent that is active against dermatophytes, has an ...

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