Pamapimod

产品详情：

更新时间： 2024-01-08 09:38:17

CAS号：449811-01-2

常用名： Pamapimod

价格：
￥需询单/1kg ￥需询单/1g ￥需询单/1mg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor. Pamapimod inhibited p38α and p38β enzymatic activity, with IC50 values of 0.014 ± 0.002 and 0.48 ± 0.04 μM, respectively. Pamapimod is p38 inhibitor with IC50 of 0.06μM in THP-1 cell.IC50: 0.014 ± 0.002 and 0.48 ± 0.04 μM(p38α and p38β enzymatic activity,respectively.)IC50:0.06μM (THP-1 cell)[1]In vitro: Pamapimod inhibited p38α and p38β enzymatic activity, with IC50 values of 0.014 ± 0.002 and 0.48 ± 0.04 μM, respectively. There was no activity against p38δ or p38γ isoforms. When profiled across 350 kinases, pamapimod bound only to four kinases in addition to p38. Cellular potency was assessed using phosphorylation of heat shock protein-27 and c-Jun as selective readouts for p38 and c-Jun NH2-terminal kinase (JNK), respectively. Pamapimod inhibited p38 (IC50, 0.06 μM), but inhibition of JNK was not detected.Pamapimod also inhibited lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) α production by monocytes, interleukin (IL)-1β production in human whole blood, and spontaneous TNFα production by synovial explants from RA patients. LPS- and TNFα-stimulated production of TNFα and IL-6 in rodents also was inhibited by pamapimod. [1]In vivo: In murine collagen-induced arthritis, pamapimod reduced clinical signs of inflammation and bone loss at 50 mg/kg or greater. In a rat model of hyperalgesia, pamapimod increased tolerance to pressure in a dose-dependent manner, suggesting an important role of p38 in pain associated with inflammation. Finally, an analog of pamapimod that has equivalent potency and selectivity inhibited renal disease in lupus-prone MRL/lpr mice. [1] 物理化学性质： CAS号：449811-01-2 常用中文名：Pamapimod 常用英文名：Pamapimod 分子式：C19H20F2N4O4 分子量：406.38300 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃

供应商信息：

公司名：上海楼岚生物科技有限公司

认证状态： 未认证供应商

商品数： 2474件

电话： 52996696

地址： 沪南路2729弄1310号

地区： 上海市浦东新区

联系人： 孙先生

联系人电话： 021-52996696

邮件：sales@lollanechem.com

网址：http://www.bioll.com

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2024-07-15 价格：需询单 Pamapimod

2022-11-29 价格：￥需询单 Pamapimod（R-1503）

2021-02-06 价格：￥4065.0 Pamapimod (R-1503, Ro4402257)

2024-03-12 价格：￥293.9 帕马皮莫德

2023-11-18 价格：￥需询单 PAMAPIMOD

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Pamapimod

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