Methyl cinnamate

Modify Date: 2025-08-21 12:07:10

Methyl cinnamate structure	Common Name	Methyl cinnamate
	CAS Number	103-26-4	Molecular Weight	162.185
	Density	1.1±0.1 g/cm3	Boiling Point	261.9±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₀O₂	Melting Point	34-38 °C(lit.)
	MSDS	Chinese USA	Flash Point	141.3±9.9 °C

Use of Methyl cinnamate

Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway[1].

Name	Methyl cinnamate
Synonym	More Synonyms

Description	Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway[1].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	In 3T3-L1 cell model, Methyl cinnamate (Methyl 3-phenylpropenoate) inhibits adipocyte differentiation by attenuating expression of the adipogenic transcription factors SREBP-1, PPARγ, and C/EBPα and the transcriptional activity of PPARγ. In addition, Methyl cinnamate (Methyl 3-phenylpropenoate) activates the CaMKK2−AMPK signaling cascade involved in the regulation of adipogenesis[1].
References	[1]. Chen YY, et al. Methyl cinnamate inhibits adipocyte differentiation via activation of the CaMKK2-AMPK pathwayin 3T3-L1 preadipocytes. J Agric Food Chem. 2012 Feb 1;60(4):955-63.

Density	1.1±0.1 g/cm3
Boiling Point	261.9±0.0 °C at 760 mmHg
Melting Point	34-38 °C(lit.)
Molecular Formula	C₁₀H₁₀O₂
Molecular Weight	162.185
Flash Point	141.3±9.9 °C
Exact Mass	162.068085
PSA	26.30000
LogP	2.18
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.559
Storage condition	0-10°C
Water Solubility	insoluble

Methyl cinnamate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GE0190000

CHEMICAL NAME :: Cinnamic acid, methyl ester

CAS REGISTRY NUMBER :: 103-26-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H10-O2

MOLECULAR WEIGHT :: 162.20

WISWESSER LINE NOTATION :: 1OV1U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2610 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,849,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,849,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83204 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 19 No. of Employees: 2695 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83204 No. of Facilities: 3528 (estimated) No. of Industries: 15 No. of Occupations: 36 No. of Employees: 57284 (estimated) No. of Female Employees: 39442 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	GE0190000
HS Code	2916399090

Precursor 10
CAS#:21770-48-9 methyl 2,3-dibr... CAS#:67-56-1 Methanol CAS#:140-10-3 Cinnamic acid CAS#:292638-85-8 acrylic acid me...
CAS#:98-80-6 Phenylboronic acid CAS#:71-43-2 benzene CAS#:77-78-1 Dimethyl sulfate CAS#:100-52-7 Benzaldehyde
CAS#:96-34-4 methyl chloroacetate CAS#:591-50-4 Iodobenzene
DownStream 10
CAS#:103-25-3 Methyl 3-phenyl... CAS#:61883-07-6 Bicyclo[8.2.0]d... CAS#:10498-83-6 Cyclopentanecar... CAS#:37088-66-7 Methyl (3S)-3-A...
CAS#:493-72-1 5-Phenylcyclohe... CAS#:108-94-1 Cyclohexanone CAS#:14441-08-8 (S)-N-Z-3-AMINO... CAS#:939-90-2 2-Phenylcyclopr...
CAS#:40546-94-9 6-Methyl-4-phen... CAS#:4165-96-2 3-Phenylpentane...

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Contribution of cinnamic acid analogues in rosmarinic acid to inhibition of snake venom induced hemorrhage.

Bioorg. Med. Chem. 19 , 2392-6, (2011)

In our previous paper, we reported that rosmarinic acid (1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid (1) consists of two phenylpropanoids: caffeic a...

BF3·OEt2-promoted diastereoselective diacetoxylation of alkenes by PhI(OAc)2.

J. Org. Chem. 76(24) , 9997-10004, (2011)

Selective syn and anti diacetoxylations of alkenes have been achieved using a PhI(OAc)(2)/BF(3)·OEt(2) system in the presence and absence of water, respectively. A broad range of substrates including ...

Stoichiometric model of alpha-cyclodextrin complex formation.

J. Pharm. Sci. 69(5) , 564-7, (1980)

The solubility, spectral, and kinetic methods were used to study complexing between alpha-cyclodextrin (ligand, L) and 3,5-dimethoxycinnamic acid, benzalacetone, and methyl cinnamate (substrates, S). ...

METHYLCINNAMATE

METHYL CINANMATE

Cinnamic acid methylester

E-3-phenyl-acrylic acid methyl ester

(E)-cinnamic acid methyl ester

TRANS-CINNAMIC ACID METHYL ESTER

cinnamic acid methyl ester

(2E)-3-Phenyl-2-propenoic acid methyl ester

trans-3-Phenylacrylic Acid Methyl Ester

METHYL-3-PHENYLPROPENOTE

Methyl (2E)-3-phenylacrylate

Methyl cinnamate

METHYL CINNAMATE/CINNAMIC ACID METHYL ESTER

EINECS 203-093-8

Methyl (E)-cinnamate

2-Propenoic acid, 3-phenyl-, methyl ester, (2E)-

CINNAMICACIDMETHYLESTER

MFCD00008458

Methyl trans-3-Phenylacrylate

METHYL 3-PHENYLACRYLATE

methyl (2E)-3-phenylprop-2-enoate

METHYL CIMNAMATE NATURAL

METHYL CINNAMYLATE

Methyl trans-cinnamate

FEMA 2698

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