Tyk2-IN-7

Modify Date: 2024-01-10 09:47:14

Tyk2-IN-7 structure	Common Name	Tyk2-IN-7
	CAS Number	1609391-90-3	Molecular Weight	401.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₅D₃N₆O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tyk2-IN-7

Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 (Compound 48) provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].

Name	Tyk2-IN-7

Description	Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 (Compound 48) provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	Tyk2 JH2:0.00053 μM (IC50) Tyk2 JH2:0.00007 μM (Ki app)
References	[1]. Moslin R, et al. Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). J Med Chem. 2019 Jul 17.

Molecular Formula	C₁₈H₁₅D₃N₆O₃S
Molecular Weight	401.46

Tyk2-IN-7

Use of Tyk2-IN-7

Names

Tyk2-IN-7 Biological Activity

Chemical & Physical Properties