Amino-PEG4-alcohol

Modify Date: 2024-01-02 19:06:11

Amino-PEG4-alcohol structure	Common Name	Amino-PEG4-alcohol
	CAS Number	86770-74-3	Molecular Weight	193.241
	Density	1.1±0.1 g/cm3	Boiling Point	301.6±27.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₉NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	136.2±23.7 °C

Use of Amino-PEG4-alcohol

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol
Synonym	More Synonyms

Description	Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. Nello Mainolfi, et al. Protein degraders and uses thereof. WO2019060742A1. [2]. Miller MA, et al. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 Dec 26;12(12):12814-12826.

Density	1.1±0.1 g/cm3
Boiling Point	301.6±27.0 °C at 760 mmHg
Molecular Formula	C₈H₁₉NO₄
Molecular Weight	193.241
Flash Point	136.2±23.7 °C
Exact Mass	193.131409
PSA	73.94000
LogP	-2.09
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.459

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: 1-Amino-3,6,9-trioxaundecanyl-11-ol
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:1-Amino-3,6,9-trioxaundecanyl-11-ol
CAS number:86770-74-3

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C8H19NO4
Molecular weight:193.2

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ6137500

CHEMICAL NAME :: Ethanol, 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-

CAS REGISTRY NUMBER :: 86770-74-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H19-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570546

HS Code	2922509090

Precursor 9
CAS#:86770-67-4 Azido-PEG4-alcohol CAS#:112-60-7 2,2'-((Oxybis(e... CAS#:77544-60-6 Tetraethylene g... CAS#:7732-18-5 Water
CAS#:106984-09-2 N-Boc-PEG4-alcohol CAS#:65883-12-7 PEG4-Ms CAS#:86770-71-0 Benzyl-PEG4-Azido CAS#:86259-87-2 Tetraethylene G...
CAS#:105891-51-8 2-[2-[2-(2-chlo...
DownStream 2
CAS#:106984-09-2 N-Boc-PEG4-alcohol CAS#:437655-95-3 Fmoc-NH-PEG4-CH2COOH

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethanol

2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol

Ethanol, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Amino-PEG4-alcohol
Price: Click To Check
Purity: 95.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Amino-PEG4-alcohol
Price: ￥730.0/100mg ￥5610.0/5g ￥1760.0/1g
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Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: Amino-PEG4-alcohol
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DC Chemicals Limited
China
Product Name: Amino-PEG4-alcohol
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Amino-PEG4-alcohol
Price: ￥Inquiry/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-(2-(2-(2-AMINOETHOXY)ETHOXY)ETHOXY)ETHANOL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥650/100 mg

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Amino-PEG4-alcohol

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