Azido-PEG4-alcohol

Modify Date: 2024-01-02 09:16:26

Azido-PEG4-alcohol Structure
Azido-PEG4-alcohol structure
Common Name Azido-PEG4-alcohol
CAS Number 86770-67-4 Molecular Weight 219.23800
Density N/A Boiling Point N/A
Molecular Formula C8H17N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azido-PEG4-alcohol


Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Azido-PEG4-alcohol Biological Activity

Description Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

 Chemical & Physical Properties

Molecular Formula C8H17N3O4
Molecular Weight 219.23800
Exact Mass 219.12200
PSA 97.67000
Index of Refraction 1.47

 Synthetic Route

 Synonyms

1-AZIDO-3,6,9-TRIOXAUNDECANE-11-OL
Azido-PEG4-alcohol
1-azido-3,6,9-trioxaundecan-11-ol
1-azido-11-hydroxy-3,6,9-trioxaundecane
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