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酪氨酸磷酸化抑制剂A9

酪氨酸磷酸化抑制剂A9用途

Tyrphostin A9(AG 17)是51种酪氨酸激酶抑制剂,是线粒体分裂诱导剂。

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酪氨酸磷酸化抑制剂A9名称

[ CAS 号 ]:
10537-47-0

[ 中文名 ]:
特螨腈

[ 英文名 ]:
Malonoben

[中文别名 ]:

[英文别名 ]:

Malonoben
MFCD00209853
Tyrphostin AG17
Tyrphostin 9
GCP 5126
Caswell No. 291AA
tyrphostin A9

酪氨酸磷酸化抑制剂A9生物活性

[ 描述 ]:

Tyrphostin A9(AG 17)是51种酪氨酸激酶抑制剂,是线粒体分裂诱导剂。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408(3):465-70.

[2]. Richard F. Loeser, Christopher B. Forsyth, Allen M. Samarel et al. Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2 Mediates Integrin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependent Pathway. The Journal of Biological Chemistry, 2003, 278, 24577-24585.

[3]. Michele Fuortes, Maxine Melchior, Hyunsil Han, et al. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest. 1999;104(3):327-335.

[4]. Johan Thyberg . Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. European Journal of Cell Biology.1998,76(1): 33-42

[5]. R Marhaba, F Mary, C Pelassy, et al. Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. The Journal of Immunology. 1996,157 (4): 1468-1473

[相关活性小分子]

酪氨酸磷酸化抑制剂A9物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
386.8±37.0 °C at 760 mmHg

[ 熔点 ]:
141-143℃ (ethanol )

[ 分子式 ]:
C₁₈H₂₂N₂O

[ 分子量 ]:
282.380

[ 闪点 ]:
187.7±26.5 °C

[ 精确质量 ]:
282.173218

[ PSA ]:
67.81000

[ LogP ]:
4.81

[ 外观性状 ]:
黄色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
ethanol: 20 mg/mL

酪氨酸磷酸化抑制剂A9MSDS

酪氨酸磷酸化抑制剂A9毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO3737000

CHEMICAL NAME :: Malononitrile, 3,5-di-tert-butyl-4-hydroxybenzylidene-

CAS REGISTRY NUMBER :: 10537-47-0

BEILSTEIN REFERENCE NO. :: 2700764

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H22-N2-O

MOLECULAR WEIGHT :: 282.42

WISWESSER LINE NOTATION :: NCYCN&U1R DQ CX1&1&1 EX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 87 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,21,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 226 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 74-1,-,1974

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酪氨酸磷酸化抑制剂A9安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H331

[ 警示性声明 ]:
P261-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S36/37/39-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
OO3737000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2926909090

酪氨酸磷酸化抑制剂A9合成路线

酪氨酸磷酸化抑制剂A9上下游产品

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酪氨酸磷酸化抑制剂A9下游产品

酪氨酸磷酸化抑制剂A9海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

酪氨酸磷酸化抑制剂A9文献

Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.

Mol. Brain 3 , 4, (2010)

Group I metabotropic glutamate receptors (mGluRs) are coupled via Galphaq/11 to the activation of phospholipase Cbeta, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and ...

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage.

FASEB J. 30 , 286-300, (2016)

Itaconate is a nonamino organic acid exhibiting antimicrobial effects. It has been recently identified in cells of macrophage lineage as a product of an enzyme encoded by immunoresponsive gene 1 (Irg1...

Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model.

Am. J. Physiol. Gastrointest. Liver Physiol. 290 , G301-G309, (2006)

The potential roles of vesicular transport and apotransferrin (entering from the blood) in intestinal Fe absorption were investigated using Caco-2 cell monolayers with tight junctions in bicameral cha...

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