< 生产厂家 价格 >

红霉素

红霉素用途

Erythromycin是口服大环内酯类抗生素,由红霉素链霉菌产生,能可逆地与细菌50S核糖体结合,抑制蛋白合成。
点击显示

红霉素名称

[ CAS 号 ]:
114-07-8

[ 中文名 ]:
红霉素

[ 英文名 ]:
Erythromycin

[中文别名 ]:

[英文别名 ]:

红霉素生物活性

[ 描述 ]:

Erythromycin是口服大环内酯类抗生素,由红霉素链霉菌产生,能可逆地与细菌50S核糖体结合,抑制蛋白合成。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬
信号通路 >> 抗感染 >> 细菌
研究领域 >> 感染
天然产物 >> 其他

[参考文献]

[1]. McCormack WM, et al. Hepatotoxicity of erythromycin estolate during pregnancy. Antimicrob Agents Chemother. 1977 Nov;12(5):630-5.

[2]. Peeters T, et al. Erythromycin is a motilin receptor agonist. Am J Physiol. 1989 Sep;257(3 Pt 1):G470-4.


[相关活性小分子]

嘌呤霉素二盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | 盐酸依拉环素 | 头孢噻肟钠

红霉素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
818.4±65.0 °C at 760 mmHg

[ 熔点 ]:
138-140ºC

[ 分子式 ]:
C37H67NO13

[ 分子量 ]:
733.927

[ 闪点 ]:
448.8±34.3 °C

[ 精确质量 ]:
733.461243

[ PSA ]:
193.91000

[ LogP ]:
2.83

[ 外观性状 ]:
松软的无色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
水溶性：实际上不溶；易溶于：丙酮,醇,氯仿；可溶于：1,2-二氯乙烷,乙醚

红霉素MSDS

详细MSDS(安全技术说明书)

红霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KF4375000
CHEMICAL NAME :
Erythromycin
CAS REGISTRY NUMBER :
114-07-8
LAST UPDATED :
199504
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C37-H67-N-O13
MOLECULAR WEIGHT :
734.05
WISWESSER LINE NOTATION :
T-14-VO GVTJ C2 DQ D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
10 mg/kg/1D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
427 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2580 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
426 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
394 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
413 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
3018 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33600 mg/kg/6W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 10-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
50 mg/kg
SEX/DURATION :
female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12 gm/kg
SEX/DURATION :
female 8-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
600 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0. ppm (11 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1050 No. of Facilities: 58 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1133 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1050 No. of Facilities: 667 (estimated) No. of Industries: 4 No. of Occupations: 12 No. of Employees: 44142 (estimated) No. of Female Employees: 37992 (estimated)
点击显示

红霉素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S24-S37-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
KF4375000

[ 海关编码 ]:
2941500000

红霉素合成路线

详细合成路线

红霉素上下游产品

红霉素上游产品

红霉素下游产品

红霉素制备

该品是由红色链丝菌（Streptomyces erythreus）培养液中提取的一种碱性抗生素。提纯时，利用它在不同的酸碱度溶解在不同溶剂中的特性，用乙酸丁酯和水溶液反复抽提，达到浓缩提纯的目的，最后在乙酸丁酯溶液中进行冷冻结晶，得红霉素碱。

点击显示

红霉素海关

[ 海关编码 ]: 2941500000

红霉素文献

Binding properties of antimicrobial agents to lipid membranes using surface plasmon resonance.

Biol. Pharm. Bull. 37(8) , 1383-9, (2014)

In the present study, we examined the interaction of antimicrobial agents with four model lipid membranes that mimicked mammalian cell membranes and Gram-positive and -negative bacterial membranes and...

Live-cell and super-resolution imaging reveal that the distribution of wall-associated protein A is correlated with the cell chain integrity of Streptococcus mutans.

Mol. Oral Microbiol. 30 , 376-83, (2015)

Streptococcus mutans is a primary pathogen responsible for dental caries. It has an outstanding ability to form biofilm, which is vital for virulence. Previous studies have shown that knockout of Wall...

Mechanisms involved in quinolone resistance in Mycoplasma mycoides subsp. capri.

Vet. J. 204 , 327-32, (2015)

Mycoplasma mycoides subsp. capri is a causative agent of contagious agalactia in goats. In this study, M. mycoides subsp. capri mutants were selected for resistance to fluoroquinolones (norfloxacin, e...


更多文献

相关化工产品/化学物质：

相关药品：

推荐生产厂家/供应商：

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥168.0/100mg ￥328.0/5g ￥88.0/1g

联系人：刘佳

产品详情：红霉素

公司名：上海如吉生物科技发展有限公司

区域：上海市静安区

价格：
￥190.0/25g

联系人：蕾蕾

产品详情：红霉素

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：E-Mycin

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥510.0/5g ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：红霉素

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥95.0/5g ￥237.0/25g ￥102.0/5g ￥261.0/25g

联系人：夏言

产品详情：[Perfemiker]红霉素,生物技术级

查看所有供应商请点击：

红霉素供应商

红霉素相关知识

红霉素的生物活性是什么？

2018-10-13 23:09:37

红霉素是口服大环内酯类抗生素，由红霉素链霉菌产生，能可逆地与细菌50S核糖体结合，抑制蛋白合成。红霉素的生理作用是通过降低皮脂腺活性来实现的。那么，红霉素的生物活性到底是什么呢？由红色链霉菌（Streptomyces erythreus）产生的口服大环内酯类抗生素红霉素可逆地结合细菌的50S核糖体...

相关化合物

【红霉素】化源网提供红霉素CAS号114-07-8，红霉素MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询红霉素上化源网，专业又轻松。>>电脑版：红霉素

标题：红霉素_MSDS_用途_密度_红霉素CAS号【114-07-8】_化源网 地址：https://m.chemsrc.com/mip/cas/114-07-8_1027933.html