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柠檬烯;双戊烯

柠檬烯;双戊烯用途

Limonene是柑橘皮油中的单萜。一种常见的消毒剂和食品防腐剂。有抗菌活性[1]。抗增殖活动[2]。抗氧化和抗炎作用[3]。

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柠檬烯;双戊烯名称

[ CAS 号 ]:
138-86-3

[ 中文名 ]:
双戊烯

[ 英文名 ]:
limonene

[中文别名 ]:

[英文别名 ]:

Cyclohexene, 4-Isopropenyl-1-methyl-
EINECS 227-815-6
p-mentha-1,8-diene
(±)-p-Mentha-1,8-diene
Mentha-1,8-diene, DL
4-(1-methylethenyl)-1-methyl-cyclohexene
Methyl-4-isopropenyl-1-cyclohexene
Limonene, dl-
Methyl-4-isopropenylcyclohexene
(±)-Limonene

柠檬烯;双戊烯生物活性

[ 描述 ]:

Limonene是柑橘皮油中的单萜。一种常见的消毒剂和食品防腐剂。有抗菌活性[1]。抗增殖活动[2]。抗氧化和抗炎作用[3]。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 癌症

研究领域 >> 炎症/免疫

研究领域 >> 感染

天然产物 >> 萜类化合物和糖苷

[ 靶点 ]

Bacterial[1]

[体外研究]

对柠檬烯的急性毒性主要归因于常见的氧化产物柠檬烯-氢过氧化物。突变蛋白AhpCL177Q 35能够通过将氢过氧化物还原成更良性的化合物来缓解这种毒性[1]。柠檬烯对淋巴瘤细胞系发挥抗增殖作用而不改变正常的淋巴细胞活力[2]。

[体内研究]

柠檬烯(50-100 mg/kg)通过局部粘膜防御机制发挥胃保护作用,如增加粘液产生,调节氧化应激和炎症反应以及抑制Nf-κb表达[3]。

[参考文献]

[1]. Chubukov V, et al. Acute Limonene Toxicity in Escherichia coli Is Caused by Limonene Hydroperoxide and Alleviated by a Point Mutation in Alkyl Hydroperoxidase AhpC. Appl Environ Microbiol. 2015 Jul;81(14):4690-6.

[2]. Roberto D, et al. Antioxidant activity of limonene on normal murine lymphocytes: relation to H2O2 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):38-44.

[3]. de Souza MC, et al. Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression. Phytomedicine. 2018 Sep 4;53:37-42.

[相关活性小分子]

柠檬烯;双戊烯物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
175.4±20.0 °C at 760 mmHg

[ 熔点 ]:
-84--104 °C

[ 分子式 ]:
C₁₀H₁₆

[ 分子量 ]:
136.234

[ 闪点 ]:
42.8±0.0 °C

[ 精确质量 ]:
136.125198

[ LogP ]:
4.45

[ 外观性状 ]:
透明至淡黄色液体,带有一种像柠檬一样的气味

[ 蒸汽密度 ]:
4.7 (vs air)

[ 蒸汽压 ]:
1.5±0.2 mmHg at 25°C

[ 折射率 ]:
1.468

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放,不宜久储,以防聚合

[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
<1 g/100mL

柠檬烯;双戊烯MSDS

柠檬烯;双戊烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS8100000

CHEMICAL NAME :: p-Mentha-1,8-diene

CAS REGISTRY NUMBER :: 138-86-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H16

MOLECULAR WEIGHT :: 136.26

WISWESSER LINE NOTATION :: L6UTJ A1 DY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,703,1974 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,703,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5550 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 24,700,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1010 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 24,700,1989

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RCTOE4 Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987- Volume(issue)/page/year: 113,47,1990 *** REVIEWS *** TOXICOLOGY REVIEW ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 78,99,1972 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1342 No. of Facilities: 3959 (estimated) No. of Industries: 70 No. of Occupations: 60 No. of Employees: 45463 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1342 No. of Facilities: 12642 (estimated) No. of Industries: 103 No. of Occupations: 90 No. of Employees: 185336 (estimated) No. of Female Employees: 45650 (estimated)

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柠檬烯;双戊烯安全信息

[ 符号 ]:

GHS02, GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H315-H317-H410

[ 警示性声明 ]:
P273-P280-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R10;R38;R43;R50/53

[ 安全声明 (欧洲) ]:
S24-S37-S60-S61

[ 危险品运输编码 ]:
UN 2052 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
OS8350000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2942000000

柠檬烯;双戊烯合成路线

柠檬烯;双戊烯上下游产品

柠檬烯;双戊烯上游产品

柠檬烯;双戊烯下游产品

柠檬烯;双戊烯制备

1.广泛存在于天然的植物精油中。其中主要含右旋体的有蜜柑油、柠檬油、香橙油、樟脑白油等。含左旋体的有薄荷油等。含消旋体的有橙花油，杉油和樟脑白油等。在制造本品时，分别由上述精油进行分馏制取，也可以从一般精油中萃取萜烯，或在加工樟脑油及合成樟脑的过程中，作为副产物制得。所得双戊烯，经蒸馏提纯可得苧烯。用松节油作原料，进行分馏、切取α-蒎烯，经异构化制莰烯，然后分馏得到。莰烯的副产物为双戊烯。此外，用松节油水合制松油醇时也可副产双戊烯。

2.氯化钙或无水硫酸钠脱水后减压蒸馏。

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柠檬烯;双戊烯海关

[ 海关编码 ]: 2942000000

柠檬烯;双戊烯文献

Materials recovery from waste liquid crystal displays: A focus on indium.

Waste Manag. 45 , 325-33, (2015)

In the present work the recovery of indium and of the polarizing film from waste liquid crystal displays was experimentally investigated in the laboratory. First of all, the polarizing film was remove...

Capturing of the monoterpene olefin limonene produced in Saccharomyces cerevisiae.

Yeast , doi:10.1002/yea.3038, (2014)

Monoterpene olefins such as limonene are plant compounds with applications as flavouring and fragrance agents, as solvents and potentially also in polymer and fuel chemistry. We engineered baker's yea...

Carbopol 934, 940 and Ultrez 10 as viscosity modifiers of palm olein esters based nano-scaled emulsion containing ibuprofen.

Pak. J. Pharm. Sci. 26(1) , 75-83, (2013)

Micro-emulsions and sometimes nano-emulsions are well known candidates to deliver drugs locally. However, the poor rheological properties are marginally affecting their acceptance pharmaceutically. Th...

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柠檬烯;双戊烯

柠檬烯;双戊烯用途

柠檬烯;双戊烯名称

柠檬烯;双戊烯生物活性

柠檬烯;双戊烯物理化学性质

柠檬烯;双戊烯MSDS

详细MSDS(安全技术说明书)

柠檬烯;双戊烯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

柠檬烯;双戊烯安全信息

柠檬烯;双戊烯合成路线

详细合成路线

柠檬烯;双戊烯上下游产品

柠檬烯;双戊烯上游产品

柠檬烯;双戊烯下游产品

柠檬烯;双戊烯制备

柠檬烯;双戊烯海关

柠檬烯;双戊烯文献

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