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左氧氟沙星半水合物

左氧氟沙星半水合物用途

Levofloxacin半水合物是抗生素化合物,抑制细菌DNA旋转酶活性。

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左氧氟沙星半水合物名称

[ CAS 号 ]:
138199-71-0

[ 中文名 ]:
(S)-(-)-9-氟-2,3-二氢-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧-7H-吡啶并[1,2,3-de]-[1,4]苯并噁嗪-6-羧酸 1/2 水合物

[ 英文名 ]:
Levofloxacin hydrate

[中文别名 ]:

[英文别名 ]:

Levofloxacin
MFCD03265511
Levofloxacin hemihydrate
Levofloxacin hydrate

左氧氟沙星半水合物生物活性

[ 描述 ]:

Levofloxacin半水合物是抗生素化合物,抑制细菌DNA旋转酶活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Siva, R., et al., Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis, 2014. 9: p. 179-86.

[2]. Pradeep, A.R., et al., Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Investig Clin Dent, 2014.

[3]. Lee, B.T., et al., Efficacy of Levofloxacin in the Treatment of BK Viremia: A Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial. Clin J Am Soc Nephrol, 2014.

[相关活性小分子]

左氧氟沙星半水合物物理化学性质

[ 密度 ]:
1.48g/cm3

[ 沸点 ]:
571.5ºC at 760mmHg

[ 熔点 ]:
214-216°C

[ 分子式 ]:
C₁₈H₂₀FN₃O_4.0.5H₂O

[ 分子量 ]:
370.38

[ PSA ]:
84.24000

[ LogP ]:
1.48260

[ 蒸汽压 ]:
6.7E-14mmHg at 25°C

[ 储存条件 ]:
-20°C Freezer

左氧氟沙星半水合物安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H317-H334-H361d-H362

[ 警示性声明 ]:
P261-P263-P280-P342 + P311

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
50/53

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

左氧氟沙星半水合物合成路线

详细合成路线

左氧氟沙星半水合物上下游产品

左氧氟沙星半水合物上游产品

左氧氟沙星半水合物下游产品

左氧氟沙星半水合物制备

由外消旋的氧氟沙星经填充特殊固定相的高效液相色谱柱直接拆分得左旋体；或将氧氟沙星以硫酸羟胺处理后，用盐酸酸化得盐酸盐，经碱性离子交换柱处理，得到的两性化合物，加入(S)-(+)-扁桃酸，其与(-)异构体成盐后形成结晶，可通过离子交换树脂，再经还原脱氨基得产品。或者以2,3,4,5-四氟苯甲酸为
原料，先制得2-(乙氧亚甲基)-3-氧代-3-(2,3,4,5-四氟苯基)丙酸乙酯后，再与(S)-2-氨基丙醇反应引入不对称碳原子，经闭环、水解、引入甲基哌嗪制得。还可以2,3,-二氟-6-硝基苯酚为原料，与R构型的对甲苯磺酸缩水甘油酯在相转移催化剂存在下反应，生成光学活性化合物，再经还原并与乙氧亚甲基丙二酸二乙酯
(EMME)缩合，最后经试剂处理，闭环、水解、引入哌嗪基得到。

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左氧氟沙星半水合物文献

Evaluation of a dental pulp-derived cell sheet cultured on amniotic membrane substrate.

Biomed Mater Eng 25(2) , 203-12, (2015)

Mesenchymal stem cells (MSC) are transplanted for periodontal tissue regeneration, and the periodontal ligament (PDL) is regenerated using a cultured cell sheet. This cultured cell sheet is prepared u...

Poly(ADP-Ribose) Polymerase Inhibition Improves Corneal Epithelial Innervation and Wound Healing in Diabetic Rats.

Invest. Ophthalmol. Vis. Sci. 56(3) , 1948-55, (2015)

We evaluated the effect of poly(ADP-ribose) polymerase (PARP) inhibition by using 1,5-isoquinolinediol (ISO) on corneal epithelial innervation in diabetic rats.ISO (3 mg/kg, intraperitoneal) or vehicl...

Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.

J. Pharm. Biomed. Anal. 102 , 9-16, (2014)

A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for thera...

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