亚麻木酚素

亚麻木酚素用途

seco-Isolariciresinol Diglucoside 是一种合成的木脂素。来源于天然植物亚麻籽。作用于巨噬细胞,降低 NLRP3 表达和 NF-κB 活化。seco-Isolariciresinol Diglucoside 还激活 Nrf2。

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亚麻木酚素名称

[ CAS 号 ]:
148244-82-0

[ 中文名 ]:
亚麻木酚素

[ 英文名 ]:
Secoisolariciresinol Diglucoside

[中文别名 ]:

[英文别名 ]:

SecoisolariciresinolDiglucoside
Flaxseed Extract
Secoisolariciresinol Diglucosi
Secoisolariciresinol diglucoside

亚麻木酚素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2

信号通路 >> 免疫及炎症 >> NOD样受体(NLR)

研究领域 >> 感染

天然产物 >> 苯丙酸类

[ 靶点 ]

NLRP3

NF-κB

Nrf2

[体外研究]

seco-Isolariciresinol Diglucoside(LGM2605)是一种具有抗炎和抗氧化特性的无毒木酚素,可用于预防小鼠腹腔巨噬细胞(MF)中的石棉。 seco-Isolariciresinol Diglucoside显着降低NLRP3从40％到81％,IL-1β为89-96％,TNFα为67-78％,活化的NF-κB为48-49％,同时硝酸盐/亚硝酸盐水平降低85-93％。 seco-Isolariciresinol Diglucoside减少石棉诱导的NLRP3表达,促炎细胞因子释放,NF-κB活化和巨噬细胞(MF)中的亚硝化应激,支持其可能用于预防导致恶性肿瘤的石棉诱导的炎症级联反应。 seco-Isolariciresinol Diglucoside抑制NF-κB的表达,防止石棉诱导的iNOS表达和小鼠腹腔巨噬细胞产生一氧化氮。 seco-Isolariciresinol Diglucoside激活Nrf2并诱导细胞抗氧化和解毒酶的表达[1]。

[参考文献]

[1]. Pietrofesa RA, et al. The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages. Oxid Med Cell Longev. 2017;2017:7395238.

[相关活性小分子]

BAY 11-7082 | ML385 | 吡咯烷二硫代甲酸铵 | MCC950 | 姜黄素 | SN50 | 雷公藤内酯醇 | 甲基巴多索隆 | 4-甲基-N1-(3-苯基丙基)-1,2-苯二胺 | 紫草素 | 叔丁基对苯二酚(TBHQ) | (2E)-3-[[4-叔丁基苯基]磺酰基]-2-丙烯腈 | CY-09 | 楝酰胺 | (-)-DHMEQ

亚麻木酚素物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
989.2±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₂H₅₀O₁₈

[ 分子量 ]:
722.73

[ 闪点 ]:
552.0±34.3 °C

[ PSA ]:
257.68000

[ LogP ]:
-2.79

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.655

[ 储存条件 ]:
2-8°C

亚麻木酚素安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932999099

亚麻木酚素海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

亚麻木酚素文献

Further studies on a human intestinal bacterium Ruminococcus sp. END-1 for transformation of plant lignans to mammalian lignans.

J. Agric. Food Chem. 57(16) , 7537-42, (2009)

A human intestinal bacterium Ruminococcus (R.) sp. END-1 capable of oxidizing (-)-enterodiol to (-)-enterolactone, enantioselectively, was further investigated from the perspective of transformation o...

Production of secoisolariciresinol from defatted flaxseed by bacterial biotransformation.

J. Appl. Microbiol. 113(6) , 1352-61, (2012)

Secoisolariciresinol (SECO) is increasingly recognized for potential clinical application because of its preventive effects against breast and colon cancers, atherosclerosis and diabetes, and its prod...

Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells.

J. Nutr. 142 , 1798-1805, (2012)

Dietary lignans show some promising health benefits, but little is known about their fate and activities in the small intestine. The purpose of this study was thus to investigate whether plant lignans...

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