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4-氯水杨酸

4-氯水杨酸用途

4-Chlorosalicylic acid是一种药物中间体。抑制单酚酶和二苯酚酶活性,IC50值分别为1.89 mM和1.10 mM。具有有效的抗菌活性。抑制大肠杆菌的MIC为250 μg/mL,MBC为500 μg/mL。

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4-氯水杨酸名称

[ CAS 号 ]:
5106-98-9

[ 中文名 ]:
4-氯水杨酸

[ 英文名 ]:
4-Chlorosalicylic acid

[中文别名 ]:

[英文别名 ]:

4-Chloro Salicylic Acid
4-Chloro-2-Hydroxy Benzoic Acid
MFCD00002449
Benzoic acid, 4-chloro-2-hydroxy-
4-Chlorosalicylic Acid
4-Chloro-2-hydroxybenzoic acid
EINECS 225-829-7

4-氯水杨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

信号通路 >> 抗感染 >> 真菌

天然产物 >> 酸和醛

研究领域 >> 感染

[ 靶点 ]

IC50: 1.89 mM (monophenolase), 1.10 mM (diphenolase)[1]

[体外研究]

4-氯水杨酸可以抑制蘑菇酪氨酸酶的二酚酶活性和单酚酶活性。 4-氯水杨酸具有广谱抗菌活性,可抑制革兰氏阳性菌和革兰氏阴性菌和真菌[1]。

[参考文献]

[1]. Han P, et al. Inhibitory effects of 4-chlorosalicylic acid on mushroom tyrosinase and its antimicrobial activities. 107 (2), 797-803, 2008

[相关活性小分子]

4-氯水杨酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
321.1±27.0 °C at 760 mmHg

[ 熔点 ]:
210-212 °C(lit.)

[ 分子式 ]:
C₇H₅ClO₃

[ 分子量 ]:
172.566

[ 闪点 ]:
148.0±23.7 °C

[ 精确质量 ]:
171.992722

[ PSA ]:
57.53000

[ LogP ]:
3.14

[ 外观性状 ]:
灰白色至淡米色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.630

[ 储存条件 ]:
室温

[ 水溶解性 ]:
slightly soluble

4-氯水杨酸MSDS

4-氯水杨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918219000

4-氯水杨酸合成路线

4-氯水杨酸上下游产品

4-氯水杨酸上游产品

4-氯水杨酸下游产品

4-氯水杨酸制备

由对氨基水杨酸经重氮化、置换而得。

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4-氯水杨酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

4-氯水杨酸文献

New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1.

J. Bacteriol. 185(23) , 6790-800, (2003)

Pseudomonas sp. strain MT1 is capable of degrading 4- and 5-chlorosalicylates via 4-chlorocatechol, 3-chloromuconate, and maleylacetate by a novel pathway. 3-Chloromuconate is transformed by muconate ...

Two angular dioxygenases contribute to the metabolic versatility of dibenzofuran-degrading Rhodococcus sp. strain HA01.

Appl. Environ. Microbiol. 74(12) , 3812-22, (2008)

Rhodococcus sp. strain HA01, isolated through its ability to utilize dibenzofuran (DBF) as the sole carbon and energy source, was also capable, albeit with low activity, of transforming dibenzo-p-diox...

Consortia modulation of the stress response: proteomic analysis of single strain versus mixed culture.

Environ. Microbiol. 12(9) , 2436-49, (2010)

The high complexity of naturally occurring microbial communities is the major drawback limiting the study of these important biological systems. In this study, a comparison between pure cultures of Ps...

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