< 生产厂家价格 >

D-赤式-二氢鞘氨醇

D-赤式-二氢鞘氨醇用途

D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A2α (cPLA2α) 活性。

点击显示

D-赤式-二氢鞘氨醇名称

[ CAS 号 ]:
764-22-7

[ 中文名 ]:
d赤dihydrosphingosine

[ 英文名 ]:
2-Amino-1,3-octadecanediol

[英文别名 ]:

erythro-Sphinganine
D-erythro-Sphinganine
2-Aminooctadecane-1,3-diol
Dihydro-C18-sphingosine
(2S,3R)-2-aminooctadecane-1,3-diol
D-erythro-2-Amino-1,3-octadecanediol
2-Amino-1,3-dihydroxyoctadecane
DL-erythro-2-Amino-1,3-octadecanediol
1,3-Octadecanediol, 2-amino-
2-Amino-1,3-octadecanediol

D-赤式-二氢鞘氨醇生物活性

[ 描述 ]:

D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A2α (cPLA2α) 活性。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷脂

研究领域 >> 癌症

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

D-赤型-二氢鞘氨醇(D-erythro-DHS)显着抑制乳腺癌,而非Na3VO4-,刺激PC12细胞中的花生四烯酸释放。 D-Erythro-dihydrosphingosine在凌晨100点轻微抑制[3H]花生四烯酸释放,单独5μM离子霉素刺激释放显着。在5μM离子霉素存在下,100μMCI-神经酰胺刺激释放,但D-赤型-二氢神经鞘氨醇(100μM)抑制释放。 D-赤型-二氢鞘氨醇抑制细胞中花生四烯酸的释放和/或cPLA2α活性[1]。

[参考文献]

[1]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17.

[相关活性小分子]

D-赤式-二氢鞘氨醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
446.2±25.0 °C at 760 mmHg

[ 熔点 ]:
70-72ºC

[ 分子式 ]:
C₁₈H₃₉NO₂

[ 分子量 ]:
301.508

[ 闪点 ]:
223.7±23.2 °C

[ 精确质量 ]:
301.298065

[ PSA ]:
66.48000

[ LogP ]:
6.27

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.478

[ 储存条件 ]:
-20°C

D-赤式-二氢鞘氨醇MSDS

详细MSDS(安全技术说明书)

D-赤式-二氢鞘氨醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

D-赤式-二氢鞘氨醇合成路线

详细合成路线

D-赤式-二氢鞘氨醇上下游产品

D-赤式-二氢鞘氨醇上游产品

D-赤式-二氢鞘氨醇下游产品

D-赤式-二氢鞘氨醇文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Lipidomic profiling reveals significant alterations in lipid biochemistry in hypothyroid rat cerebellum and the therapeutic effects of Sini decoction.

J. Ethnopharmacol. 159 , 262-73, (2014)

Hypothyroidism is known to be closely associated with lipid metabolism. Although our previous serum and urine metabonomics studies have provided some clues about the molecular mechanism of hypothyroid...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

更多文献