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神经激肽A

神经激肽A用途

Neurokinin A 通过 NK-2 受体发挥作用。

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神经激肽A名称

[ CAS 号 ]:
86933-74-6

[ 中文名 ]:
神经激肽A

[ 英文名 ]:
Neurokinin A trifluoroacetate salt

[英文别名 ]:

Neurokinin A [NKA]
MFCD00167560
A-neurokinin
HKTDSFVGLM-NH2

神经激肽A生物活性

[ 描述 ]:

Neurokinin A 通过 NK-2 受体发挥作用。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体

信号通路 >> 神经信号通路 >> 神经激肽受体

研究领域 >> 神经疾病

多肽产品

[ 靶点 ]

NK-2 receptor[1]

[体外研究]

神经激肽A(物质K)是速激肽家族的肽神经递质,具有作为人气道和胃肠组织中的主要介质的潜力。神经激肽A通过NK-2受体起作用,该受体被认为定位于平滑肌细胞上并与GTP结合蛋白药理学偶联。神经激肽A是称为速激肽的肽神经递质家族的成员。这些肽与中枢和外周神经系统相关并显示出广泛的组织分布。速激肽共享COOH-末端结构Phe-X-Gly-Leu-Met-NH。这个家族中最着名的成员是物质P和神经激肽A或物质K [1]。

[参考文献]

[1]. Gerard NP, et al. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62.

[相关活性小分子]

神经激肽A物理化学性质

[ 密度 ]:
1.305 g/cm3

[ 沸点 ]:
1610.7ºC at 760 mmHg

[ 分子式 ]:
C₅₀H₈₀N₁₄O₁₄S

[ 分子量 ]:
1133.32000

[ 闪点 ]:
927.9ºC

[ 精确质量 ]:
1132.57000

[ PSA ]:
488.77000

[ LogP ]:
1.05310

[ 外观性状 ]:
白色至灰白色冻干的固体

[ 折射率 ]:
1.58

[ 储存条件 ]:
-20°C

神经激肽A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

神经激肽A文献

Neurogenic airway inflammation induced by repeated intra-esophageal instillation of HCl in guinea pigs.

Inflammation 36(2) , 493-500, (2013)

This study was conducted to investigate if repeated intra-esophageal acid administrations may induce neurogenic inflammation in the airways and nodose ganglion in a guinea pig model. Guinea pigs were ...

Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.

Neuropeptides 47(1) , 9-18, (2013)

The present study was planned to evaluate role of tachykinins (TKs) and neurokinin (NK) receptors in the regulation of gastric motility in sheep. We examined the effects of intravenous (i.v.) injectio...

Neuromodulation mediated by the tachykinin NK3-receptor agonist [MePhe7]-neurokinin B in the isolated perfused lung of nonsensitized nonchallenged and ovalbumin-sensitized and -challenged guinea pig.

Exp. Lung Res. 38(5) , 233-49, (2012)

The neuromodulatory action of the tachykinin NK(3)-receptor agonist [MePhe(7)]-neurokinin B ([MePhe(7)]-NKB) was evaluated on vagal stimulation-induced bronchoconstriction in nonsensitized nonchalleng...

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