Azide-PEG4-Tos

Modify Date: 2025-08-26 21:19:12

Azide-PEG4-Tos Structure
Azide-PEG4-Tos structure
 Common Name Azide-PEG4-Tos
CAS Number 168640-82-2 Molecular Weight 373.42500
Density N/A Boiling Point N/A
Molecular Formula C15H23N3O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azide-PEG4-Tos


Azide-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-1-(2-methylphenyl)sulfonylethanol
Synonym More Synonyms

 Azide-PEG4-Tos Biological Activity

Description Azide-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C15H23N3O6S
Molecular Weight 373.42500
Exact Mass 373.13100
PSA 140.19000
LogP 1.98076
Storage condition 2-8°C

 Synthetic Route

Azido-PEG4-alcohol structure

Azido-PEG4-alcohol

CAS#:86770-67-4

Tosyl chloride structure

Tosyl chloride

CAS#:98-59-9

~93%

Azide-PEG4-Tos Structure

Azide-PEG4-Tos

CAS#:168640-82-2

Literature: Yue, Xuyi; Feng, Yue; Yu, Y. Bruce Journal of Fluorine Chemistry, 2013 , vol. 152, p. 173 - 181
PROTAC Linker 16 structure

PROTAC Linker 16

CAS#:37860-51-8

~78%

Azide-PEG4-Tos Structure

Azide-PEG4-Tos

CAS#:168640-82-2

Literature: Dao, Kinh-Luan; Sawant, Rupa R.; Hendricks, J. Adam; Ronga, Victoria; Torchilin, Vladimir P.; Hanson, Robert N. Bioconjugate Chemistry, 2012 , vol. 23, # 4 p. 785 - 795
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol structure

2,2'-((Oxybis(e...

CAS#:112-60-7

~%

Azide-PEG4-Tos Structure

Azide-PEG4-Tos

CAS#:168640-82-2

Literature: Meunier, Serge J.; Wu, Quigquan; Wang, Sho-Nong; Roy, Rene Canadian Journal of Chemistry, 1997 , vol. 75, # 11 p. 1472 - 1482
Tosyl chloride structure

Tosyl chloride

CAS#:98-59-9

~%

Azide-PEG4-Tos Structure

Azide-PEG4-Tos

CAS#:168640-82-2

Literature: Gobbo, Pierangelo; Novoa, Samantha; Biesinger, Mark C.; Workentin, Mark S. Chemical Communications, 2013 , vol. 49, # 38 p. 3982 - 3984
Tetraethylene glycol monotosylate structure

Tetraethylene g...

CAS#:77544-60-6

~%

Azide-PEG4-Tos Structure

Azide-PEG4-Tos

CAS#:168640-82-2

Literature: Yue, Xuyi; Feng, Yue; Yu, Y. Bruce Journal of Fluorine Chemistry, 2013 , vol. 152, p. 173 - 181

 Synonyms

11-azido-3,6,9-trioxa-undecanyl p-toluenesulfonate
2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
toluene-4-sulfonic acid 2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl ester
2-[2-[2-(2-AZIDOETHOXY)ETHOXY]ETHOXY]-1-(P-TOLUENESULFONYL)-ETHANOL
2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethyl tosylate
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