m-PEG3-SH

Modify Date: 2024-01-21 11:52:52

m-PEG3-SH structure	Common Name	m-PEG3-SH
	CAS Number	31521-83-2	Molecular Weight	180.26500
	Density	1.017	Boiling Point	N/A
	Molecular Formula	C₇H₁₆O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of m-PEG3-SH

m-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-(1-Ethoxyethoxy)-2-methoxyethanethiol
Synonym	More Synonyms

Description	m-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.017
Molecular Formula	C₇H₁₆O₃S
Molecular Weight	180.26500
Exact Mass	180.08200
PSA	66.49000
LogP	1.28780

HS Code	2930909090

m-PEG3-S-Acetyl

CAS#:857284-78-7

~78%

m-PEG3-SH

CAS#:31521-83-2

Literature: Keddie, Daniel J.; Grande, John B.; Gonzaga, Ferdinand; Brook, Michael A.; Dargaville, Tim R. Organic Letters, 2011 , vol. 13, # 22 p. 6006 - 6009

m-PEG3-Tos

CAS#:62921-74-8

~72%

m-PEG3-SH

CAS#:31521-83-2

Literature: Ruizendaal, Loes; Pujari, Sidharam P.; Gevaerts, Veronique; Paulusse, Jos M. J.; Zuilhof, Han Chemistry - An Asian Journal, 2011 , vol. 6, # 10 p. 2776 - 2786

m-PEG3-OH

CAS#:112-35-6

m-PEG3-SH

CAS#:31521-83-2

Literature: Keddie, Daniel J.; Grande, John B.; Gonzaga, Ferdinand; Brook, Michael A.; Dargaville, Tim R. Organic Letters, 2011 , vol. 13, # 22 p. 6006 - 6009

Methyl-PEG3-bromide

CAS#:72593-77-2

thiourea

CAS#:17356-08-0

~65%

m-PEG3-SH

CAS#:31521-83-2

Literature: Dabak, Salih; Ahsen, Vefa; Heinemann, Frauke; Zugenmaier, Peter Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2000 , vol. 348, p. 111 - 127

Azide-PEG4-Tos

CAS#:168640-82-2

m-PEG3-SH

CAS#:31521-83-2

Literature: Gobbo, Pierangelo; Novoa, Samantha; Biesinger, Mark C.; Workentin, Mark S. Chemical Communications, 2013 , vol. 49, # 38 p. 3982 - 3984

PROTAC Linker 16

CAS#:37860-51-8

m-PEG3-SH

CAS#:31521-83-2

Literature: Gobbo, Pierangelo; Novoa, Samantha; Biesinger, Mark C.; Workentin, Mark S. Chemical Communications, 2013 , vol. 49, # 38 p. 3982 - 3984

S-Acetyl-PEG3-azide

CAS#:1310827-26-9

m-PEG3-SH

CAS#:31521-83-2

Literature: Gobbo, Pierangelo; Novoa, Samantha; Biesinger, Mark C.; Workentin, Mark S. Chemical Communications, 2013 , vol. 49, # 38 p. 3982 - 3984

HS-PEG3-CH2CH2N3

CAS#:1347750-79-1

m-PEG3-SH

CAS#:31521-83-2

Literature: Gobbo, Pierangelo; Novoa, Samantha; Biesinger, Mark C.; Workentin, Mark S. Chemical Communications, 2013 , vol. 49, # 38 p. 3982 - 3984

2,2'-((Oxybis(e...

CAS#:112-60-7

m-PEG3-SH

CAS#:31521-83-2

Literature: Gobbo, Pierangelo; Novoa, Samantha; Biesinger, Mark C.; Workentin, Mark S. Chemical Communications, 2013 , vol. 49, # 38 p. 3982 - 3984

Precursor 8
CAS#:857284-78-7 m-PEG3-S-Acetyl CAS#:62921-74-8 m-PEG3-Tos CAS#:112-35-6 m-PEG3-OH CAS#:72593-77-2 Methyl-PEG3-bromide
CAS#:168640-82-2 Azide-PEG4-Tos CAS#:37860-51-8 PROTAC Linker 16 CAS#:1347750-79-1 HS-PEG3-CH2CH2N3 CAS#:112-60-7 2,2'-((Oxybis(e...
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