m-PEGn-NHS ester

Modify Date: 2024-02-25 17:17:18

m-PEGn-NHS ester Structure
m-PEGn-NHS ester structure
Common Name m-PEGn-NHS ester
CAS Number 174569-25-6 Molecular Weight 1787.0688
Density N/A Boiling Point N/A
Molecular Formula (C2H4O)nC8H11NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of m-PEGn-NHS ester


m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Methoxy-PEG-propionicacid-N-succinimidylester

 m-PEGn-NHS ester Biological Activity

Description m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Molecular Formula (C2H4O)nC8H11NO5
Molecular Weight 1787.0688
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