m-PEG4-NHS ester

Modify Date: 2024-01-03 00:38:22

m-PEG4-NHS ester Structure
m-PEG4-NHS ester structure
Common Name m-PEG4-NHS ester
CAS Number 622405-78-1 Molecular Weight 333.334
Density 1.2±0.1 g/cm3 Boiling Point 431.7±55.0 °C at 760 mmHg
Molecular Formula C14H23NO8 Melting Point N/A
MSDS N/A Flash Point 214.9±31.5 °C

 Use of m-PEG4-NHS ester


m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

 Names

Name (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propanoate
Synonym More Synonyms

 m-PEG4-NHS ester Biological Activity

Description m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 431.7±55.0 °C at 760 mmHg
Molecular Formula C14H23NO8
Molecular Weight 333.334
Flash Point 214.9±31.5 °C
Exact Mass 333.142365
PSA 100.60000
LogP -2.87
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.490
Storage condition -20°C

 Synthetic Route

~70%

m-PEG4-NHS ester Structure

m-PEG4-NHS ester

CAS#:622405-78-1

Literature: BIOCON LIMITED Patent: US2011/118480 A1, 2011 ; Location in patent: Page/Page column 5 ;

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m-PEG4-NHS ester Structure

m-PEG4-NHS ester

CAS#:622405-78-1

Literature: BIOCON LIMITED Patent: US2011/118480 A1, 2011 ;

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m-PEG4-NHS ester Structure

m-PEG4-NHS ester

CAS#:622405-78-1

Literature: BIOCON LIMITED Patent: US2011/118480 A1, 2011 ;

 Synonyms

N-Succinimidyl 4,7,10,13-Tetraoxatetradecanoate
1-[(14-Oxo-2,5,8,11-tetraoxatetradecan-14-yl)oxy]-2,5-pyrrolidinedione
Methyl-PEG4-NHS Ester
4,7,10,13-Tetraoxatetradecanoic Acid N-Succinimidyl Ester
2,5-Pyrrolidinedione, 1-[(1-oxo-4,7,10,13-tetraoxatetradec-1-yl)oxy]-
AmbotzPEG1880
1-(4,7,10,13-tetraoxatetradecan-1-oyloxy)pyrrolidine-2,5-dione
N-hydroxysuccinimidyl 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propanoate
M2186
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