COX-2-IN-20

Modify Date: 2023-02-23 12:47:25

COX-2-IN-20 structure	Common Name	COX-2-IN-20
	CAS Number	2529451-43-0	Molecular Weight	269.66
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₉ClFN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of COX-2-IN-20

COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity[1].

Name	COX-2-IN-20

Description	COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:17.9 nM (IC50) COX-1:19.3 μM (IC50)
In Vitro	COX-2-IN-20 (Compound 5d) shows potential anti-inflammatory activity on NO inhibition in LPS-induced RAW 264.7 cell with an IC50 of 2.87 μM[1].
In Vivo	COX-2-IN-20 (Compound 5d) (5 mg/kg) exhibits better in vivo anti-inflammation and gastric protection than 10 mg/kg Indomethacin[1].
References	[1]. Li SM, et al. New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study. Bioorg Chem. 2020 Nov;104:104333.

Molecular Formula	C₁₁H₉ClFN₃O₂
Molecular Weight	269.66