DNA topoisomerase II inhibitor 1
Modify Date: 2025-08-27 08:09:08
DNA topoisomerase II inhibitor 1 structure
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Common Name | DNA topoisomerase II inhibitor 1 | ||
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| CAS Number | 2459950-15-1 | Molecular Weight | 496.58 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H24N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DNA topoisomerase II inhibitor 1DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase[1]. |
| Name | DNA topoisomerase II inhibitor 1 |
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| Description | DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase[1]. |
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| Related Catalog | |
| In Vitro | DNA topoisomerase II inhibitor 1 (compound 8ed) (0-10 µM; 48 h) shows cytotoxic activity with IC50s of 10.10, >10, 0.59, 4.20, >10, >10, 8.41 µM for HT-29, MDA-MB-231, MG-63, U87MG, PC3, HeLa, Vero cells, respectively[1]. DNA topoisomerase II inhibitor 1 (0.5, 2 µM; 24 h) induces apoptosis and cell cycle arrest at sub G1 phase[1]. DNA topoisomerase II inhibitor 1 (0.5, 2 µM) increases the generation of reactive oxygen species (ROS)[1]. |
| References |
| Molecular Formula | C28H24N4O3S |
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| Molecular Weight | 496.58 |