Bromo-PEG5-alcohol

Modify Date: 2024-01-09 20:41:01

Bromo-PEG5-alcohol Structure
Bromo-PEG5-alcohol structure
Common Name Bromo-PEG5-alcohol
CAS Number 957205-14-0 Molecular Weight 301.17500
Density 1.3±0.1 g/cm3 Boiling Point 364.6±32.0 °C at 760 mmHg
Molecular Formula C10H21BrO5 Melting Point N/A
MSDS N/A Flash Point 174.3±25.1 °C

 Use of Bromo-PEG5-alcohol


Bromo-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 14-Bromo-3,6,9,12-tetraoxatetradecan-1-ol
Synonym More Synonyms

 Bromo-PEG5-alcohol Biological Activity

Description Bromo-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 364.6±32.0 °C at 760 mmHg
Molecular Formula C10H21BrO5
Molecular Weight 301.17500
Flash Point 174.3±25.1 °C
Exact Mass 300.05700
PSA 57.15000
LogP -0.89
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.475

 Safety Information

Hazard Codes Xi

 Synonyms

14-Bromo-3,6,9,12-tetraoxatetradecan-1-ol
3,6,9,12-Tetraoxatetradecan-1-ol, 14-bromo-