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戊唑醇

戊唑醇用途

Tebuconazole 是一种农用唑类杀菌剂也能抑制 CYP51 ,对于白色念珠菌 CYP51 (CaCYP51) 和截段的人 CYP51 (Δ60HsCYP51) 的 IC50 值分别为 0.9 和 1.3 μM。

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戊唑醇名称

[ CAS 号 ]:
107534-96-3

[ 中文名 ]:
戊唑醇

[ 英文名 ]:
tebuconazole

[中文别名 ]:

立克秀

[英文别名 ]:

Tebuconazole
Lynx 1.2
MFCD02674797
HORIZON
RAXIL
FOLICUR
MATADOR
LYNX
Tebuconazol
ELITE

戊唑醇生物活性

[ 描述 ]:

Tebuconazole 是一种农用唑类杀菌剂也能抑制 CYP51 ,对于白色念珠菌 CYP51 (CaCYP51) 和截段的人 CYP51 (Δ60HsCYP51) 的 IC50 值分别为 0.9 和 1.3 μM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[ 靶点 ]

IC50: 0.9 μM (CaCYP51), 1.3 μM (Δ60HsCYP51)[1]

[参考文献]

[1]. Warrilow AG, et al. Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother. 2013 Mar;57(3):1352-60.

[相关活性小分子]

戊唑醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
476.9±55.0 °C at 760 mmHg

[ 熔点 ]:
102-105°C

[ 分子式 ]:
C₁₆H₂₂ClN₃O

[ 分子量 ]:
307.818

[ 闪点 ]:
242.2±31.5 °C

[ 精确质量 ]:
307.145142

[ PSA ]:
50.94000

[ LogP ]:
3.58

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.564

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
32 mg/L at 20 ºC

戊唑醇MSDS

戊唑醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ4803270

CHEMICAL NAME :: 1H-1,2,4-Triazole-1-ethanol, alpha-(2-(4-chlorophenyl)ethyl)-alpha-(1,1-dimethylet hyl)-, (+-)-

CAS REGISTRY NUMBER :: 107534-96-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C16-H23-Cl-N3-O

MOLECULAR WEIGHT :: 308.87

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C294,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >800 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,785,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C294,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,785,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 4488 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,785,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - domestic

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,785,1991

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戊唑醇安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H361d-H411

[ 警示性声明 ]:
P273-P281

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R22;R51/53;R63

[ 安全声明 (欧洲) ]:
S2-S22-S36/37-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ RTECS号 ]:
XZ4803270

[ 海关编码 ]:
2933990015

戊唑醇合成路线

戊唑醇制备

先将4-氯苯甲基频哪酮与（CH3）3S⁺I^-反应，制得相应的环氧衍生物。然后再与1，2，4-三唑反应，制得戊唑醇。

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戊唑醇海关

[ 海关编码 ]: 2933990015

[ 中文概述 ]:
2933990015 苄氯三唑醇,戊菌唑,粉唑醇等〔包括联苯三唑醇,腈菌唑,环丙唑醇,烯唑醇,戊唑醇,氟硅唑〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2933990015 3-((1h-1,2,4-triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

戊唑醇文献

Development of a multi-residue method in a fetal matrix: analysis of meconium.

Anal. Bioanal. Chem 406(30) , 7785-97, (2014)

Meconium is the earliest stool of newborns. It is a complex matrix that reflects the degree of fetal exposure to environmental pollutants. To investigate exposure to xenobiotics, an analytical method ...

Molecular characterization, fitness and mycotoxin production of benzimidazole-resistant isolates of Penicillium expansum.

Int. J. Food Microbiol. 162(3) , 237-44, (2013)

Penicillium expansum field-strains resistant to benzimidazole fungicides were isolated in high frequency from decayed apple fruit collected from packinghouses and processing industries located in the ...

Development of a new cucumber reference material for pesticide residue analysis: feasibility study for material processing, homogeneity and stability assessment.

Anal. Bioanal. Chem 407(11) , 3083-91, (2015)

The feasibility of the production of a reference material for pesticide residue analysis in a cucumber matrix was investigated. Cucumber was spiked at 0.075 mg/kg with each of the 15 selected pesticid...

更多文献

戊唑醇

戊唑醇用途

戊唑醇名称

戊唑醇生物活性

戊唑醇物理化学性质

戊唑醇MSDS

详细MSDS(安全技术说明书)

戊唑醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

戊唑醇安全信息

戊唑醇合成路线

详细合成路线

戊唑醇制备

戊唑醇海关

戊唑醇文献

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