< 生产厂家价格 >

琥乙红霉素

琥乙红霉素用途

Erythromycin乙基琥珀酸盐是一种抗生素,用于治疗多种细菌感染,具有与青霉素类似或稍宽于青霉素的抗菌谱。

点击显示

琥乙红霉素名称

[ CAS 号 ]:
1264-62-6

[ 中文名 ]:
磺胺噻唑

[ 英文名 ]:
Erythromycin Ethylsuccinate

[中文别名 ]:

琥乙红霉素

[英文别名 ]:

ERYTHROMYCIN ETHYISUCCINATE
ERYTHROCINETHYLSUCCINATE
ErythromycinEthylsuccinate
Erythromycin ethylsuccinate
ERYTHROMYCIN ETHYL SUCCINATE
ERYTHROMYCIN ETHYLSUCCINATE API

琥乙红霉素生物活性

[ 描述 ]:

Erythromycin乙基琥珀酸盐是一种抗生素,用于治疗多种细菌感染,具有与青霉素类似或稍宽于青霉素的抗菌谱。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

琥乙红霉素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
874.1±65.0 °C at 760 mmHg

[ 熔点 ]:
219-224ºC

[ 分子式 ]:
C₄₃H₇₅NO₁₆

[ 分子量 ]:
862.053

[ 闪点 ]:
482.4±34.3 °C

[ 精确质量 ]:
861.508606

[ PSA ]:
226.28000

[ LogP ]:
4.10

[ 外观性状 ]:
白色至淡黄色结晶固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
ethanol: soluble50mg/mL | Freely soluble in organic solvents, practically insoluble in water

琥乙红霉素MSDS

琥乙红霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM9800000

CHEMICAL NAME :: Succinic acid, monoethyl ester, monoester with erythromycin

CAS REGISTRY NUMBER :: 1264-62-6

BEILSTEIN REFERENCE NO. :: 0077638

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C43-H75-N-O16

MOLECULAR WEIGHT :: 862.19

WISWESSER LINE NOTATION :: T-14-VO GVTJ C2 DQ D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 420 mg/kg/7D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Liver - other changes

REFERENCE :: CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 129,411,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5714 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 10,616,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4167 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,445,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,126,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0949 No. of Facilities: 113 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3065 (estimated) No. of Female Employees: 1433 (estimated)

点击显示

琥乙红霉素安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WM9800000

[ 海关编码 ]:
2941500000

琥乙红霉素合成路线

琥乙红霉素上下游产品

琥乙红霉素上游产品

琥乙红霉素下游产品

琥乙红霉素海关

[ 海关编码 ]: 2941500000

琥乙红霉素文献

Hapten synthesis, monoclonal antibody production and development of a competitive indirect enzyme-linked immunosorbent assay for erythromycin in milk.

Food Chem. 171 , 98-107, (2014)

Erythromycin is an antibiotic used extensively in veterinary practice worldwide for treatment, prevention and growth promotion. In this work, monoclonal antibodies (Mabs) against erythromycin were pro...

Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications.

J. Sep. Sci. 33(9) , 1305-11, (2010)

A sensitive approach for the simultaneous determination of tilmicosin, erythromycin ethylsuccinate and clindamycin was developed by CE coupled with electrochemiluminescence detection with ionic liquid...

Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs.

J. Vet. Pharmacol. Ther. 31(6) , 496-500, (2008)

The purpose of this study was to describe and compare the pharmacokinetic properties of different formulations of erythromycin in dogs. Erythromycin was administered as lactobionate (10 mg/kg, IV), es...

更多文献