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二氢麻醉椒苦素

二氢麻醉椒苦素用途

二氢麻醉椒苫素(Dihydromethysticin)卡瓦内酯，具有诱导CYP3A23活性。

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二氢麻醉椒苦素名称

[ CAS 号 ]:
19902-91-1

[ 中文名 ]:
二氢麻醉椒素

[ 英文名 ]:
Dihydromethysticin

[中文别名 ]:

[英文别名 ]:

DIHYDROMETHYSTICIN

二氢麻醉椒苦素生物活性

[ 描述 ]:

二氢麻醉椒苫素(Dihydromethysticin)卡瓦内酯,具有诱导CYP3A23活性。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

天然产物 >> 其他

研究领域 >> 其他

[参考文献]

[1]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24.

[2]. Walden J, et al. Effects of kawain and dihydromethysticin on field potential changes in the hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):697-706.

[3]. Sarris J, et al. Kava: a comprehensive review of efficacy, safety, and psychopharmacology. Aust N Z J Psychiatry. 2011 Jan;45(1):27-35.

[相关活性小分子]

二氢麻醉椒苦素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
476.1±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₆O₅

[ 分子量 ]:
276.284

[ 闪点 ]:
214.1±28.8 °C

[ 精确质量 ]:
276.099762

[ PSA ]:
53.99000

[ LogP ]:
1.81

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.576

[ 储存条件 ]:
2-8°C

二氢麻醉椒苦素MSDS

详细MSDS(安全技术说明书)

二氢麻醉椒苦素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0516000

CHEMICAL NAME :: 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)phenethy l)-, (S)-

CAS REGISTRY NUMBER :: 19902-91-1

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H16-O5

MOLECULAR WEIGHT :: 276.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,505,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 26,283,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,505,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,505,1962