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普罗地芬 盐酸盐

普罗地芬 盐酸盐用途

Proadifen盐酸盐是一种细胞色素P450抑制剂(IC50 = 19μM).
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普罗地芬 盐酸盐名称

[ CAS 号 ]:
62-68-0

[ 中文名 ]:
α-苯基-α-丙基苯乙酸-2-(二乙氨)乙酯 N,N-二乙氨乙基-2,2-二苯戊酸酯

[ 英文名 ]:
Proadifen hydrochloride

[中文别名 ]:

[英文别名 ]:

普罗地芬 盐酸盐生物活性

[ 描述 ]:

Proadifen盐酸盐是一种细胞色素P450抑制剂(IC50 = 19μM).

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
研究领域 >> 其他

[相关活性小分子]

n-[4-[2-乙基-1-(1H-1,2,4-噻唑-1-基)丁基]苯基]-2-苯并噻唑胺 | 芹菜素; 芹黄素; 5,7,4'-三羟基黄酮 | 可比司他 | 人参皂苷CK | 吉非罗齐 | 艾沙康唑 | 柚皮苷 | 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-C]咪唑-7-基]-N-甲基-2-萘甲酰胺 | 高良姜素; 3,5,7-三羟基黄酮 | (3BETA)-17-(1H-苯并咪唑-1-基)雄甾-5,16-二烯-3-醇 | 四氢姜黄素 | 1-氨基苯并三唑 | 呋拉茶碱 | 人参皂苷 F1 | 五味子甲素

普罗地芬 盐酸盐物理化学性质

[ 沸点 ]:
460.8ºC at 760 mmHg

[ 熔点 ]:
122-123ºC

[ 分子式 ]:
C23H32ClNO2

[ 分子量 ]:
389.959

[ 闪点 ]:
132.3ºC

[ 精确质量 ]:
389.212158

[ PSA ]:
29.54000

[ LogP ]:
5.45980

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Store in Freezer

[ 水溶解性 ]:
Soluble in methanol or water

普罗地芬 盐酸盐MSDS

详细MSDS(安全技术说明书)

普罗地芬 盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV7175000
CHEMICAL NAME :
Valeric acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER :
62-68-0
LAST UPDATED :
199206
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C23-H31-N-O2.Cl-H
MOLECULAR WEIGHT :
390.01
WISWESSER LINE NOTATION :
3XR&R&VO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 111,131,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
163 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,366,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
538 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 111,131,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - reactivates cholinesterase
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 3,508,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,366,1972
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,118,1966
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,118,1966
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
>10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,118,1966 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
20 mg/kg
SEX/DURATION :
female 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. Volume(issue)/page/year: 19,264,1960
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普罗地芬 盐酸盐安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YV7175000

普罗地芬 盐酸盐文献

Effects of cytochrome P450 inhibitors on peroxidase activity.

Neuro Endocrinol. Lett. 33 Suppl 3 , 33-40, (2012)

Of several enzymes metabolizing xenobiotics, cytochrome P450 (CYP) and peroxidase enzymes seem to be most important. One of the major challenges in studies investigating metabolism of xenobiotics is t...

Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis.

PLoS ONE 10(2) , e0116961, (2015)

Methamphetamine is a highly addictive psychostimulant that causes profound damage to the brain and other body organs. Post mortem studies of human tissues have linked the use of this drug to diseases ...

Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum.

J. Physiol. Sci. 62(3) , 211-9, (2012)

Serine proteases are versatile signaling molecules and often exert this function by activating the proteinase-activated receptors (PAR(1)-PAR(4)). Our previous study on the mouse cecum has shown that ...


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