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桂利嗪

桂利嗪用途

Cinnarizine是抗组胺剂和钙通道阻断剂, 促进脑血流, 用于治疗脑中风, 创伤后脑症状, 脑动脉硬化。
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桂利嗪名称

[ CAS 号 ]:
298-57-7

[ 中文名 ]:
桂利嗪

[ 英文名 ]:
cinnarizine

[中文别名 ]:

[英文别名 ]:

桂利嗪生物活性

[ 描述 ]:

Cinnarizine是抗组胺剂和钙通道阻断剂, 促进脑血流, 用于治疗脑中风, 创伤后脑症状, 脑动脉硬化。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道
信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
信号通路 >> 免疫及炎症 >> 组胺受体
研究领域 >> 心血管疾病

[相关活性小分子]

硫酸新霉素 | 硝苯地平 | 氯化乙酰胆碱； 乙酰氯化胆碱 | 氯雷他定 | 离子霉素 | (S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氢吡啶-3-甲酸甲酯 | 尼莫地平 | 米贝拉地尔 | 组胺 | 左乙拉西坦 | CDN1163 | 丹曲林钠 | 1-[3-[3-(4-氯丙基)丙氧基]丙基]-哌啶盐酸盐 | 毒胡萝卜素 | 西咪替丁

桂利嗪物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
509.2±38.0 °C at 760 mmHg

[ 熔点 ]:
117-120ºC

[ 分子式 ]:
C26H28N2

[ 分子量 ]:
368.514

[ 闪点 ]:
229.8±14.6 °C

[ 精确质量 ]:
368.225250

[ PSA ]:
6.48000

[ LogP ]:
4.63

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.626

[ 储存条件 ]:
Refrigerator

桂利嗪MSDS

详细MSDS(安全技术说明书)

桂利嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL3430000
CHEMICAL NAME :
Piperazine, 1-cinnamyl-4-(diphenylmethyl)-
CAS REGISTRY NUMBER :
298-57-7
BEILSTEIN REFERENCE NO. :
0626121
LAST UPDATED :
199709
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C26-H28-N2
MOLECULAR WEIGHT :
368.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
252 mg/kg/12W-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951- Volume(issue)/page/year: 112,607,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
22500 mg/kg/22W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes
REFERENCE :
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 26,928,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6500 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,1735,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 21,443,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,515,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,1735,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4500 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,1735,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 21,443,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,515,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,1735,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,515,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,515,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,515,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18750 mg/kg/30D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,1748,1982 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
193 mg/kg
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - impotence
REFERENCE :
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 27,370,1993
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3750 mg/kg
SEX/DURATION :
female 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,1748,1982
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桂利嗪安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
TL3430000

[ 海关编码 ]:
2933599090

桂利嗪合成路线

详细合成路线

桂利嗪上下游产品

桂利嗪上游产品

桂利嗪下游产品

桂利嗪制备

由无水哌嗪与溴代二苯甲烷制取二苯甲基哌嗪，再与苯丙烯氯缩合而得。二苯甲烷在光照下加热，滴加溴素，在130℃保温1h，即得溴代二苯甲烷，C13H11Br，[776-74-9]，熔点45℃。将溴代二苯甲烷滴加到哌嗪甲苯液中，于80-90℃搅拌3h，冷却后用水洗涤反应液，再用10%稀盐酸萃取，将酸层碱化析出沉淀，过滤烘干，得二苯甲基哌嗪。将其溶解在95%乙醇中，加入碳酸钠，在65℃左右滴加苯丙烯氯，滴完后，加热回流4h，趁热过滤，滤液放置过液，析出结晶，过滤，得脑益嗪粗品，经精制，得熔点117-119℃的成品。以二苯甲烷计，总收率48.2%。

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桂利嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

桂利嗪文献

Iron oxide induced enhancement of mucoadhesive potential of Eudragit RLPO: formulation, evaluation and optimization of mucoadhesive drug delivery system.

Expert Opin. Drug Deliv. 10(9) , 1179-91, (2013)

The objective of the study was to investigate the effect of iron oxide in the development of mucoadhesive tablets of cinnarizine using Eudragit RLPO polymer. A simplex lattice design was employed for ...

A combination turbidity and supernatant microplate assay to rank-order the supersaturation limits of early drug candidates.

J. Pharm. Sci. 103(10) , 3022-32, (2014)

A unique opportunity exists at the drug discovery stage to overcome inherently poor solubility by selecting drug candidates with superior supersaturation propensity. Existing supersaturation assays co...

Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds.

J. Phys. Chem. B 118(33) , 9974-82, (2014)

Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly i...


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推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：肉桂嗪

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Cinnarizine

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥489.0/100mg ￥1489.0/500mg ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Cinnarizine

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥199.9/10g ￥51.9/1g ￥799.9/50g ￥379.9/1ml

联系人：阿拉丁

产品详情：桂利嗪

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥168.0/1g ￥275.0/5g ￥791.0/25g ￥490.0/100mg

联系人：夏言

产品详情：[Perfemiker]桂利嗪,≥98%

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相关化合物

【桂利嗪】化源网提供桂利嗪CAS号298-57-7，桂利嗪MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询桂利嗪上化源网，专业又轻松。>>电脑版：桂利嗪

标题：桂利嗪_MSDS_用途_密度_桂利嗪CAS号【298-57-7】_化源网 地址：https://m.chemsrc.com/mip/cas/298-57-7_946825.html