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恩贝灵； 恩贝酸

恩贝灵； 恩贝酸用途

Embelin是可渗透入细胞的,有抗癌特性的苯醌化合物。
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恩贝灵； 恩贝酸名称

[ CAS 号 ]:
550-24-3

[ 中文名 ]:
恩贝酸

[ 英文名 ]:
Embelin

[中文别名 ]:

[英文别名 ]:

恩贝灵； 恩贝酸生物活性

[ 描述 ]:

Embelin是可渗透入细胞的,有抗癌特性的苯醌化合物。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> IAP
天然产物 >> 醌类
研究领域 >> 癌症

[参考文献]

[1]. Siegel C, et al. miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7.

[2]. Hu R, et al. Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. Med Oncol. 2011 Dec;28(4):1584-8.

[3]. Siegelin MD, et al. The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP. Neurochem Int. 2009 Nov;55(6):423-30.

[4]. Kalyan Kumar G, et al. Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice. Eur J Pharmacol. 2011 Jul 15;662(1-3):63-9.

[5]. Kumar G K, et al. Embelin ameliorates dextran sodium sulfate-induced colitis in mice. Int Immunopharmacol. 2011 Jun;11(6):724-31.

[6]. Xue Z, et al. Embelin suppresses dendritic cell functions and limits autoimmune encephalomyelitis through the TGF-β/β-catenin and STAT3 signaling pathways. Mol Neurobiol. 2014 Apr;49(2):1087-101.


[相关活性小分子]

LCL161 | 比瑞那帕 | BV6 | AZD5582 | SM-164 | GDC-0152 | CUDC-427 | AT-406 | ASTX660 | MX-69 | UC-112

恩贝灵； 恩贝酸物理化学性质

[ 密度 ]:
1.131

[ 沸点 ]:
431.9±45.0 °C at 760 mmHg

[ 熔点 ]:
145-146 ºC

[ 分子式 ]:
C17H26O4

[ 分子量 ]:
294.386

[ 闪点 ]:
229.1±25.2 °C

[ 精确质量 ]:
294.183105

[ PSA ]:
74.60000

[ LogP ]:
5.70

[ 外观性状 ]:
solid

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.538

[ 储存条件 ]:
Store at +4°C

[ 水溶解性 ]:
DMSO: >10 mg/mL

恩贝灵； 恩贝酸MSDS

详细MSDS(安全技术说明书)

恩贝灵； 恩贝酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DK4230000
CHEMICAL NAME :
p-Benzoquinone, 2,5-dihydroxy-3-undecyl-
CAS REGISTRY NUMBER :
550-24-3
BEILSTEIN REFERENCE NO. :
1885786
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C17-H26-O4
MOLECULAR WEIGHT :
294.43
WISWESSER LINE NOTATION :
L6V DVJ BQ C11 EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
44 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 21,31,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5040 mg/kg/6W-I
TOXIC EFFECTS :
Liver - multiple effects Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
REFERENCE :
PHYREH Phytotherapy Research. (Heyden & Son Ltd., Spectrum House, Hillview Gardens, London, NW4 2JQ, UK) V.1- 1987- Volume(issue)/page/year: 8,257,1994 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
JRIHDC Journal of Research in Indian Medicine Yoga and Homoeopathy. (Banaras Hindu Univ., Varanasi-5, India) V.11- 1976- Volume(issue)/page/year: 11(4),84,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 18,1359,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,1187,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
300 mg/kg
SEX/DURATION :
male 15 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 39,307,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4 gm/kg
SEX/DURATION :
male 14 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year: 15,486,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JRIHDC Journal of Research in Indian Medicine Yoga and Homoeopathy. (Banaras Hindu Univ., Varanasi-5, India) V.11- 1976- Volume(issue)/page/year: 11(4),84,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
210 mg/kg
SEX/DURATION :
male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male Endocrine - androgenic
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 44,311,1991
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恩贝灵； 恩贝酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DK4230000

[ 海关编码 ]:
2914690090

恩贝灵； 恩贝酸合成路线

详细合成路线

恩贝灵； 恩贝酸上下游产品

恩贝灵； 恩贝酸上游产品

恩贝灵； 恩贝酸下游产品

恩贝灵； 恩贝酸海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

恩贝灵； 恩贝酸文献

Preventive effect of embelin from embelia ribes on lipid metabolism and oxidative stress in high-fat diet-induced obesity in rats.

Planta Med. 78(7) , 651-7, (2012)

A high-fat diet (HFD) results in hyperlipidemia and an increase in oxidative stress. The purpose of this study was to investigate the preventive effect of embelin against hyperlipidemia and oxidative ...

Embelin ameliorates dextran sodium sulfate-induced colitis in mice

Int. Immunopharmacol. 11(6) , 724-31, (2011)

Embelin has been used to treat fever, inflammatory diseases, and a variety of gastrointestinal ailments for thousands of years. Although reports indicate that embelin has anti-inflammatory and anti-tu...

Inhibition of UVB-induced oxidative damage and apoptotic biochemical changes in human lymphocytes by 2,5-dihydroxy-3-undecyl-1,4-benzoquinone (embelin).

Int. J. Radiat. Biol. 88(8) , 575-82, (2012)

The present study investigates the inhibition of Ultraviolet B (UVB, 290-320 nm) radiation-induced oxidative damage in peripheral blood human lymphocytes by embelin extracted from Embelia ribes.Embeli...


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产品详情：恩贝灵

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价格：
￥433.0/10mg

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产品详情：[Perfemiker]恩贝酸,分析对照品，98%

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产品详情：恩贝酸

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恩贝灵； 恩贝酸相关知识

恩贝酸的作用 - 生物活性 - 靶点活性

2018-11-20 22:58:19

恩贝酸，别名恩贝灵，英文名Embelin。它是一种具有抗肿瘤特性的细胞渗透性苯醌化合物。通过直接靶向Smac和胱天蛋白酶-9结合结构域BIR3（在与Smac肽的竞争性结合测定中IC 50 = 4.1uM），特异性地拮抗XIAP介导的对胱天蛋白酶-9活化的抑制。那么它的生物活性是什么？如何做实验呢？...

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