< 生产厂家价格 >

木香烃内酯

木香烃内酯用途

Costunolide有抗炎和抗氧化活性，能介导凋亡。

点击显示

木香烃内酯名称

[ CAS 号 ]:
553-21-9

[ 中文名 ]:
木香烃内酯

[ 英文名 ]:
Costunolide

[中文别名 ]:

木香烯内酯

[英文别名 ]:

Costunlide
costunolid
Costulide
MFCD00210262
Costunolide
COSTUNDIDE
CUSTUNOLIDE

木香烃内酯生物活性

[ 描述 ]:

Costunolide有抗炎和抗氧化活性,能介导凋亡。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

天然产物 >> 萜类化合物和糖苷

[参考文献]

[1]. Cheon YH, Song MJ, Kim JY, Costunolide Inhibits Osteoclast Differentiation by Suppressing c-Fos Transcriptional Activity. Phytother Res. 2013 Jul 6.

[2]. Rasul A, Bao R, Malhi M, Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules. 2013 Jan 24;18(2):1418-33.

[3]. Kretschmer N, Rinner B, Stuendl N, Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells. Planta Med. 2012 Nov;78(16):1749-56.

[4]. Matsuda H, Shimoda H, Ninomiya K, Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion. Alcohol Alcohol. 2002 Mar-Apr;37(2):121-7.

[相关活性小分子]

木香烃内酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
385.4±42.0 °C at 760 mmHg

[ 熔点 ]:
106 °C

[ 分子式 ]:
C₁₅H₂₀O₂

[ 分子量 ]:
232.318

[ 闪点 ]:
162.0±25.3 °C

[ 精确质量 ]:
232.146332

[ PSA ]:
26.30000

[ LogP ]:
4.05

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.519

[ 储存条件 ]:
Store at -20°C

木香烃内酯MSDS

详细MSDS(安全技术说明书)

木香烃内酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LY4270000

CHEMICAL NAME :: Germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-, gamma-lactone, (E,E)-

CAS REGISTRY NUMBER :: 553-21-9

LAST UPDATED :: 198605

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H20-O2

MOLECULAR WEIGHT :: 232.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 12500 ppb

REFERENCE :: BSECBU Biochemical Systematics and Ecology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.2- 1974- Volume(issue)/page/year: 13,365,1985

点击显示

木香烃内酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H317-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

木香烃内酯上下游产品

木香烃内酯上游产品

木香烃内酯下游产品

木香烃内酯制备

从菊科植物云木香 (Saussurea lappa Clarke) 的根中提取。用于治疗血吸虫病。

点击显示

木香烃内酯文献

Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang.

J. Ethnopharmacol. 156 , 182-9, (2014)

Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, t...

Simultaneous quantification of curdione, furanodiene and germacrone in rabbit plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.

Biomed. Chromatogr. 29 , 1393-8, (2015)

A simple, rapid and sensitive method was developed for the simultaneous quantification of curdione, furanodiene and germacrone in rabbit plasma using a LC-MS/MS analysis. The plasma sample preparation...

A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.

Toxicol. Appl. Pharmacol. 289 , 177-84, (2015)

Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, inte...

更多文献

木香烃内酯

木香烃内酯用途

木香烃内酯名称

木香烃内酯生物活性

木香烃内酯物理化学性质

木香烃内酯MSDS

详细MSDS(安全技术说明书)

木香烃内酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

木香烃内酯安全信息

木香烃内酯上下游产品

木香烃内酯上游产品

木香烃内酯下游产品

木香烃内酯制备

木香烃内酯文献

相关化工产品/化学物质：

相关药品：

推荐生产厂家/供应商：

相关化合物