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盐酸雷洛昔芬

盐酸雷洛昔芬用途

Raloxifene hydrochloride (LY156758 hydrochloride) 是第二代雌激素受体拮抗剂。

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盐酸雷洛昔芬名称

[ CAS 号 ]:
82640-04-8

[ 中文名 ]:
盐酸雷洛昔芬

[ 英文名 ]:
Raloxifene HCl

[中文别名 ]:

雷洛西芬中间体

[英文别名 ]:

Raloxifene HCl
MFCD01938233
Raloxifene hydrochloride
Raloxifene (hydrochloride)

盐酸雷洛昔芬生物活性

[ 描述 ]:

Raloxifene hydrochloride (LY156758 hydrochloride) 是第二代雌激素受体拮抗剂。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 内分泌

[参考文献]

[1]. Yang, N.N., et al., Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology, 1996. 137(5): p. 2075-84.

[2]. Obach, R.S., Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos, 2004. 32(1): p. 89-97.

[3]. Sato, M., M.K. Rippy, and H.U. Bryant, Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J, 1996. 10(8): p. 905-12.

[4]. Black, L.J., et al., Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest, 1994. 93(1): p. 63-9.

[5]. Evans, G., et al., The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology, 1994. 134(5): p. 2283-8.

[相关活性小分子]

盐酸雷洛昔芬物理化学性质

[ 密度 ]:
1.285g/cm3

[ 沸点 ]:
728.2ºC at 760 mmHg

[ 熔点 ]:
143-147ºC

[ 分子式 ]:
C₂₈H₂₈ClNO₄S

[ 分子量 ]:
510.044

[ 闪点 ]:
394.2ºC

[ 精确质量 ]:
509.142761

[ PSA ]:
98.24000

[ LogP ]:
6.81510

[ 外观性状 ]:
淡黄色固体

[ 折射率 ]:
1.654

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
DMSO: 28 mg/mL, soluble

盐酸雷洛昔芬安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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盐酸雷洛昔芬文献

Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.

Drug Metab. Dispos. 42(8) , 1326-33, (2014)

Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pa...

Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway.

J. Steroid Biochem. Mol. Biol. 145 , 85-93, (2015)

Growing evidence shows that steroid hormones, especially 17β-estradiol (E2), protect neuronal cells by attenuating excess activation of microglia. However, the use of E2 in the clinic is controversial...

Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening.

Assay Drug Dev. Technol. 12(9-10) , 514-26, (2014)

Abstract The central role of nicotinamide adenine dinucleotides in cellular energy metabolism and signaling makes them important nodes that link the metabolic state of cells with energy homeostasis an...

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