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KC7F2

KC7F2用途

KC7F2是一种有效的HIF-1途径抑制剂，可用作癌症治疗剂。

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KC7F2名称

[ CAS 号 ]:
927822-86-4

[ 中文名 ]:
KC7F2

[ 英文名 ]:
KC7F2

[英文别名 ]:

UNII-94C2DMM81L
KC7f2

KC7F2生物活性

[ 描述 ]:

KC7F2是一种有效的HIF-1途径抑制剂,可用作癌症治疗剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶

研究领域 >> 癌症

[参考文献]

[1]. Narita T, et al. Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res. 2009 Oct 1;15(19):6128-6136.

[2]. Koh MY, et al. Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin Cancer Res. 2009 Oct 1;15(19):5945-5946.

[相关活性小分子]

KC7F2物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
708.8±70.0 °C at 760 mmHg

[ 分子式 ]:
C₁₆H₁₆Cl₄N₂O₄S₄

[ 分子量 ]:
570.381

[ 闪点 ]:
382.5±35.7 °C

[ 精确质量 ]:
567.874695

[ PSA ]:
159.70000

[ LogP ]:
6.39

[ 外观性状 ]:
white solid

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.643

[ 储存条件 ]:
-20℃

KC7F2MSDS

详细MSDS(安全技术说明书)

KC7F2安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

KC7F2文献

Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome.

Nat. Cell Biol. 17(4) , 511-23, (2015)

The functional significance of the overexpression of unmutated TAp73, a homologue of the tumour suppressor p53, in multiple human cancers is unclear, but raises the possibility of unidentified roles i...

Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma.

Brain Tumor Pathol. 32(1) , 31-40, (2015)

Accumulating evidence shows that the expression level of Oct-3/4, a self-renewal regulator in stem cells, is positively correlated with the progression of various solid tumors. However, little is know...

Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia.

Mol. Vis. 19 , 1-15, (2013)

The prosurvival signaling cascades that mediate the unique ability of human lens epithelial cells to survive in their naturally hypoxic environment are not well defined. Hypoxia induces the synthesis ...

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