二甲基乙二酰氨基乙酸 | PT-2385 | 罗沙司他 | PX-478 | BAY 87-2243 | Vadadustat | 达普司他 | 绿原酸 | 3-[[[4-(金刚烷-1-基)苯氧基]乙酰基]氨基]-4-羟基苯甲酸甲酯 | 莫立司他 | N-[[4-羟基-2-氧代-1-(苯基甲基)-1,2-二氢-3-喹啉基]羰基]甘氨酸 | 芍药苷 | KC7F2 | 千层纸素A | JNJ-42041935

吡噻硫酮物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
408.1±55.0 °C at 760 mmHg

[ 熔点 ]:
165-166ºC

[ 分子式 ]:
C₈H₆N₂S₃

[ 分子量 ]:
226.342

[ 闪点 ]:
200.6±31.5 °C

[ 精确质量 ]:
225.969315

[ PSA ]:
114.35000

[ LogP ]:
1.92

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.760

[ 储存条件 ]:
2-8°C

吡噻硫酮MSDS

详细MSDS(安全技术说明书)

吡噻硫酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP1293000

CHEMICAL NAME :: 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-

CAS REGISTRY NUMBER :: 64224-21-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H6-N2-S3

MOLECULAR WEIGHT :: 226.34

WISWESSER LINE NOTATION :: T6N DNJ B- ET5SSYJ CUS D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 43 mg/kg/D

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10920 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 9100 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 21840 mg/kg/1Y-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mg/L

REFERENCE :: CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,379,1986

点击显示

吡噻硫酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
JP1293000

[ 海关编码 ]:
2933990090

吡噻硫酮合成路线

详细合成路线

吡噻硫酮上下游产品

吡噻硫酮上游产品

吡噻硫酮下游产品

吡噻硫酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吡噻硫酮文献

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Diabetes 63(10) , 3483-96, (2014)

This study investigated the impact of catalase (Cat) overexpression in renal proximal tubule cells (RPTCs) on nuclear factor erythroid 2-related factor 2 (Nrf2) stimulation of angiotensinogen (Agt) ge...

Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz.

Expert Opin. Drug Metab. Toxicol. 6(2) , 213-24, (2010)

Comprehensive studies indicate that oltipraz exerts cancer chemopreventive effects. Oltipraz has other therapeutic potentials, which include anti-fibrotic effect, inhibition of insulin resistance, mit...

Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.

Oncol. Rep. 21(6) , 1559-65, (2009)

Inducers of phase II detoxifying enzymes have been studied as chemopreventive agents for a variety of cancers. Phase II detoxifying enzymes may play a significant role in preventing carcinogen-induced...

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吡噻硫酮

吡噻硫酮用途

吡噻硫酮名称

吡噻硫酮生物活性