Hydroxy-PEG3-(CH2)2-Boc structure
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Common Name | Hydroxy-PEG3-(CH2)2-Boc | ||
|---|---|---|---|---|
| CAS Number | 186020-66-6 | Molecular Weight | 278.34200 | |
| Density | 1.057g/cm3 | Boiling Point | 365.8ºC at 760 mmHg | |
| Molecular Formula | C13H26O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 125.2ºC | |
Use of Hydroxy-PEG3-(CH2)2-BocHydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1]. |
| Name | tert-butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate |
|---|---|
| Synonym | More Synonyms |
| Description | Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1]. |
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| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Density | 1.057g/cm3 |
|---|---|
| Boiling Point | 365.8ºC at 760 mmHg |
| Molecular Formula | C13H26O6 |
| Molecular Weight | 278.34200 |
| Flash Point | 125.2ºC |
| Exact Mass | 278.17300 |
| PSA | 74.22000 |
| LogP | 0.76030 |
| Vapour Pressure | 7.78E-07mmHg at 25°C |
| Index of Refraction | 1.45 |
| InChIKey | KSXVEOLRERRELV-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCOCCO |
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2918990090 |
|
~94%
Hydroxy-PEG3-(C... CAS#:186020-66-6 |
| Literature: Wilbur, D. Scott; Pathare, Pradip M.; Hamlin, Donald K.; Wan, Feng Patent: US2006/228325 A1, 2006 ; Location in patent: Page/Page column 63 ; |
| Precursor 2 | |
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| DownStream 1 | |
| HS Code | 2918990090 |
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| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Angew. Chem. Int. Ed. Engl. 113 , 379, (2001)
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| Hydroxy-PEG3-t-butyl ester |
| 12-hydroxy-4,7,10-trioxadodecanoic acid tert-butyl ester |
| tert-Butyl triethylene glycol-O-propionate |
| tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate |