Topoisomerase II inhibitor 12

Modify Date: 2024-04-03 07:02:56

Topoisomerase II inhibitor 12 structure	Common Name	Topoisomerase II inhibitor 12
	CAS Number	2304527-20-4	Molecular Weight	649.95
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₆₃N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Topoisomerase II inhibitor 12

Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity[1].

Name	Topoisomerase II inhibitor 12

Description	Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
In Vitro	Topoisomerase II inhibitor 12 (Compound 8c) shows anti-proliferative activities with IC50 values of 8.80 ± 0.12, 7.13 ± 0.20, 6.56 ± 0.15, 10.99 ± 0.23, 10.71 ± 0.03 and 13.27 ± 0.32 μM against HepG2, HCT116, MDA-MB-231, Hela, K562 and PDLSC cells, respectively[1].
References	[1]. Xie XW, et al. Design, synthesis, bioevaluation of LFC- and PA-tethered anthraquinone analogues of mitoxantrone. Bioorg Chem. 2020 Aug;101:104005.

Molecular Formula	C₄₀H₆₃N₃O₄
Molecular Weight	649.95