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双去甲氧基姜黄素

双去甲氧基姜黄素用途

双去甲氧基姜黄素(Bisdemethoxycurcumin)是姜黄素衍生物,具有抗炎症和抗癌活性。

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双去甲氧基姜黄素名称

[ CAS 号 ]:
33171-05-0

[ 中文名 ]:
双去甲氧基姜黄素

[ 英文名 ]:
Bisdemethoxycurcumin

[中文别名 ]:

[英文别名 ]:

bis(4-hydroxycinnamoyl)methane
Bis(p-hydroxycinnamoyl)methane
Bisdemethoxycurcumin

双去甲氧基姜黄素生物活性

[ 描述 ]:

双去甲氧基姜黄素(Bisdemethoxycurcumin)是姜黄素衍生物,具有抗炎症和抗癌活性。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

信号通路 >> 自噬 >> 自噬

天然产物 >> 酚类

研究领域 >> 癌症

[参考文献]

[1]. Lee PJ, et al. Bisdemethoxycurcumin Induces Apoptosis in Activated Hepatic Stellate Cells via Cannabinoid Receptor 2. Molecules. 2015 Jan 14;20(1):1277-92.

[2]. Chen J, et al. Natural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells. Food Funct. 2014 Dec 24.

[3]. Luo C, et al. Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncol Lett. 2015 Jan;9(1):270-274.

[4]. Li YB, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714.

[相关活性小分子]

双去甲氧基姜黄素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
551.3±45.0 °C at 760 mmHg

[ 熔点 ]:
221-223ºC

[ 分子式 ]:
C₁₉H₁₆O₄

[ 分子量 ]:
308.328

[ 闪点 ]:
301.3±25.2 °C

[ 精确质量 ]:
308.104858

[ PSA ]:
74.60000

[ LogP ]:
3.39

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.680

[ 储存条件 ]:
-20°C

双去甲氧基姜黄素安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

双去甲氧基姜黄素文献

An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo...

Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts.

Anal. Bioanal. Chem 407(3) , 803-12, (2015)

This paper describes the synthesis of novel molecularly imprinted polymers (MIPs), prepared by a noncovalent imprinting approach, for cleanup and preconcentration of curcumin (CUR) and bisdemethoxycur...

Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity.

Eur. J. Med. Chem. 45 , 4446-57, (2010)

Curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3), the curcuminoid constituents of the medicinal plant Curcuma longa L., have been structurally modified to 55 analogs and antimycobacter...

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双去甲氧基姜黄素

双去甲氧基姜黄素用途

双去甲氧基姜黄素名称

双去甲氧基姜黄素生物活性

双去甲氧基姜黄素物理化学性质

双去甲氧基姜黄素安全信息

双去甲氧基姜黄素文献

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