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唑尼沙胺钠

唑尼沙胺钠用途

Zonisamide钠为1,2苯异恶唑衍生物,有抗癫痫活性。

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唑尼沙胺钠名称

[ CAS 号 ]:
68291-98-5

[ 中文名 ]:
唑尼沙胺钠

[ 英文名 ]:
Zonisamide sodium

[中文别名 ]:

1,2-苯并恶唑-3-甲磺酰胺钠盐

[英文别名 ]:

sodium,1,2-benzoxazol-3-ylmethylsulfonylazanide
Zonisamide (sodium)

唑尼沙胺钠生物活性

[ 描述 ]:

Zonisamide钠为1,2苯异恶唑衍生物,有抗癫痫活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 神经疾病

[参考文献]

[1]. Peters DH, et al. Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy. Drugs. 1993 May;45(5):760-87.

[2]. Brodie MJ, et al. Zonisamide as adjunctive therapy for refractory partial seizures. Epilepsy Res. 2006 Feb;68 Suppl 2:S11-6. Epub 2005 Nov 28.

[相关活性小分子]

唑尼沙胺钠物理化学性质

[ 沸点 ]:
457.2ºC at 760 mmHg

[ 分子式 ]:
C₈H₇N₂NaO₃S

[ 分子量 ]:
234.208

[ 精确质量 ]:
234.007507

[ PSA ]:
80.58000

[ LogP ]:
2.18320

[ 外观性状 ]:
灰白色固体

[ 储存条件 ]:
2-8℃

唑尼沙胺钠MSDS

详细MSDS(安全技术说明书)

唑尼沙胺钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

唑尼沙胺钠文献

Application of surfactant assisted dispersive liquid-liquid microextraction as an efficient sample treatment technique for preconcentration and trace detection of zonisamide and carbamazepine in urine and plasma samples.

J. Chromatogr. A. 1308 , 25-31, (2013)

A simple, rapid, and efficient method, based on surfactant assisted dispersive liquid-liquid microextraction (SA-DLLME), followed by high performance liquid chromatography (HPLC) has been developed fo...

Zonisamide in clinical practice.

Acta Neurol. Scand.,. Suppl.c. (194) , 29-35, (2012)

Zonisamide is currently licensed in Europe and the USA for the adjunctive treatment of partial seizures (with or without secondary generalization) in adults, based on the results of four pivotal, rand...

Zonisamide in the treatment of bulimia nervosa: an open-label, pilot, prospective study.

Int. J. Eat. Disord. 46(7) , 747-50, (2013)

To assess preliminarily the effectiveness of zonisamide in bulimia nervosa.This was an open-label, prospective, 12-week, flexible dose study of zonisamide in bulimia nervosa. The primary outcome was b...

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