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抗菌肽 B

抗菌肽 B用途

Cecropin B 有着高水平的抗菌活性,且是一种有价值的肽类抗菌素。

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抗菌肽 B名称

[ CAS 号 ]:
80451-05-4

[ 中文名 ]:
抗菌肽 B

[ 英文名 ]:
Cecropin B

[英文别名 ]:

KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL-NH2

抗菌肽 B生物活性

[ 描述 ]:

Cecropin B 有着高水平的抗菌活性,且是一种有价值的肽类抗菌素。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 癌症

多肽产品

[体外研究]

Cecropin B-诱导NF-κB活化通过破坏PXR /类视黄醇X受体α(RXR-α)复合物与DNA序列的结合在抑制CYP3A29中起关键作用。 Cecropin B通过与TLRs 2和4相互作用激活猪肝细胞,TLRs 2和4调节NF-κB介导的信号通路[1]。

[体内研究]

伤口湿润,C组渗出较多,而其他组则干燥,无明显渗出。每组中大多数小鼠的体温升高,但每组中白细胞的数量在手术后降低。 A组肌肉细菌数量明显低于M组和C组。 C组4个PID后存活小鼠的数量明显少于A组和M组(P <0.05)[2]。

[动物实验]

小鼠[1]将30只ICR小鼠纳入研究，并通过切除1cm×1cm面积的背皮全层来复制铜绿假单胞菌感染模型。然后将它们随机分为C组（对照组，n = 10，在伤后3小时（PIH）用等压生理盐水湿敷），M（在3 PIH下用100g / L的磺胺类药物进行亲水性压缩），A（湿敷）在3个PIH）组中的1 000 mg / L天蚕素B。在损伤前和伤后4天测定各组体温和血象的变化[2]。

[参考文献]

[1]. Zhou X et al. Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway. Sci Rep. 2016 Jun 14

[2]. Ren HT et al. [The antibacterial effect of cecropin B on pseudomonas aeruginosa infection of wounds in mice].Zhonghua Shao Shang Za Zhi. 2006 Dec;22(6):445-7.

[相关活性小分子]

抗菌肽 B物理化学性质

[ 分子式 ]:
C₁₇₆H₃₀₂N₅₂O₄₁S

[ 分子量 ]:
3834.67

[ 储存条件 ]:
-20°C

抗菌肽 B安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

抗菌肽 B文献

Transcriptional analysis of a Photorhabdus sp. variant reveals transcriptional control of phenotypic variation and multifactorial pathogenicity in insects.

Appl. Environ. Microbiol. 77 , 1009-20, (2011)

Photorhabdus luminescens lives in a mutualistic association with entomopathogenic nematodes and is pathogenic for insects. Variants of Photorhabdus frequently arise irreversibly and are studied becaus...

Comparative mode of action of novel hybrid peptide CS-1a and its rearranged amphipathic analogue CS-2a.

FEBS J. 279(20) , 3776-90, (2012)

Cell selective, naturally occurring, host defence cationic peptides present a good template for the design of novel peptides with the aim of achieving a short length with improved antimicrobial potenc...

Surface functionalization of titanium substrates with cecropin B to improve their cytocompatibility and reduce inflammation responses.

Colloids Surf. B Biointerfaces 110 , 225-35, (2013)

Bacteria-related inflammation is a common postoperative complication in orthopedic implantation. In this study, cecropin B (CecB), a cationic peptide, was immobilized onto the surfaces of titanium sub...

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