Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.
Histone H3 (1-25), amide is an N-terminal peptide fragment of histone H3. Histone H3 (1-25), amide can be used to identify the substrate for histone methyltransferases (HMTs). Histone H3 (1-25), amide, as a substrate for HMT G9a, shows more efficient than histone H3 (15-39) and full-length histone H3[1].
1-Bromoundecane-d23 is the deuterium labeled 1-Bromoundecane[1].
13β-Hydroxylupanine is a natural product that can be found in Caulophyllum robustum Maxim[1].
Bio-Soft S 101 (sodium) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Retinol, palmitate, 9-cis,13-cis- is the palmitate isomer of vitamin A. Retinol, palmitate, 9-cis,13-cis- can be test bioactivity through rat vaginal smear assays[1].
MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).IC50 value: 1.6 nM (Ki, for mouse), 25 nM (Ki, for human) [1]Target: BRS-3in vitro: MK-5046 is a novel BRS-3 agonist, with improved BRS-3 potency, specificity, and pharmacokinetic properties that allows in-depth investigation of BRS3 agonism in preclinical species and is also potentially suitable for use in humans. MK-5046 exhibits no appreciable binding activity at the neuromedin B and gastrin-releasing peptide receptors, as well as many other receptors, ion channels, and enzymes. In a cell-based Ca2+ mobilization functional assay, MK-5046 activates human BRS-3 with similar agonist efficacy as the peptide BRS-3 agonist.[1] MK-5046 is a potent, selective bombesin receptor subtype-3 agonist for the treatment of obesity.[2]in vivo: MK-5046 is the first BRS-3 agonist with properties suitable for use in larger mammals. In dogs, MK-5046 treatment produced statistically significant and persistent weight loss, which was initially accompanied by increases in body temperature and heart rate that abated with continued dosing. MK-5046 also effectively reduced body weight in rats and caused modest increases in body temperature, heart rate, and blood pressure. MK-5046 in rodents and dogs and further support BRS-3 agonism as a new approach to the treatment of obesity.[1]
Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus.
3’-Azido-3’-deoxy-5-methoxyuridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Durantoside I is a natural product, that can be isolated from the stems of Duranta erecta[1].
DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry[1].
3,4,5-Trichlorosyringol is a chlorophenolic compound synthetised by chlorination of syringol in carbon disulphide (CS2)[1].
CHEMBL333994 is a potent and orally effective Cholecystokinin A (CCK-A) antagonist, with an IC50 of 0.67 nM.
Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselective alpha-adrenergic antagonist.
Motugivatrep is the potent antagonist of transient receptor potential type 1 (TRPV1). Motugivatrep has a wide range of usefulness in treating drugs, urine tabletops, and respiratory diseases (extracted from patent WO2007010383A1)[1].
Lauryl Phosphate is a bioactive chemical.
Fmoc-Cys(4-MeBzl)-OH is a cysteine derivative[1].
H-Tyr-Lys-OH is a dipeptide that can be used as a biomarker for AJH-1. H-Tyr-Lys-OH has a good binding affinity to angiotensin converting enzyme (ACE)[1].
Gastrin/CCK antagonist 1 is an antagonist of gastrin/CCK, used for the research of gastrointestinal disorders.
12-Oxograndiflorenic acid is a natural product that can be isolated from vegetative Ambrosia hispida. Synonyms is ent-12-oxokaura-9(11),16-dien-19-oic acid[1].
L-Altrose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
1,3-Dibromo-5-fluorobenzene-d3 is the deuterium labeled 1,3-Dibromo-5-fluorobenzene[1].
SQI-Pr is a conductive Na+ ionophore that selectively increases Na+ conductance in human neutrophils[1].
epi-Syringaresinol is a phenolic compound isolated from Sapium discolor[1].
Dabsyl-L-methionine is a Methionine (HY-13694) derivative[1].
PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη[1].
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli[1][2][3].
Thaumatins is a protein, which can be purified from the fruit of Thaumatococ?cus daniellii Benth. Thaumatins is 100,000 times sweeter than sucrose on a molar basis[1].
Octodrine (2-Amino-6-methylheptane) is a local anesthetic and vasoconstrictor, but mainly as a pharmaceutical intermediate of Octamylamine.
4-(Phenyldiazenyl)benzoic acid is a photosensitive and photoswitchable TRPA1 agonist that can be used as pharmacological tools for study of pain signaling.