GLPG0492 is a novel selective androgen receptor modulator; exhibited anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.IC50 value:Target: AR modulatorGLPG0492 has very good pharmacokinetic properties, including bioavailability in rat (F > 50%), and is currently under evaluation in phase I clinical trials [1]. GLPG0492 is a new non-steroidal selective androgen receptor modulator that is currently under development for musculo-skeletal diseases such as sarcopenia and cachexia. In acute exhaustion tests, a surrogate of the 6-min walking test used in DMD patients, GLPG0492 preserved running performance, whereas vehicle- or comparator-treated animals showed a significant increase in fatigue (30-50%) [2]. GLPG0492 treatment partially prevents immobilization-induced muscle atrophy with a trend to promote muscle fiber hypertrophy in a dose-dependent manner. Interestingly, GLPG0492 was found as efficacious as TP at reducing muscle loss while sparing reproductive tissues. Furthermore, gene expression studies performed on tibialis samples revealed that both GLPG0492 and TP were slowing down muscle loss by negatively interfering with major signaling pathways controlling muscle mass homeostasis [3].
(R)-2-formamido-4-methylpentanoic acid is a leucine derivative[1].
Methyl 2-amino-2-cyclopropylacetate hydrochloride is a Glycine (HY-Y0966) derivative[1].
Tyrosinase (192-200), human mouse is a nonapeptide. Tyrosinase (192-200), human mouse can be recognized by cytolytic T cell (CTL) on the HLA-B44 molecule. Tyrosinase (192-200), human mouse can be used in research of melanoma associated cancers[1].
680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a Ki of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease[1][2][3][4].
PhIP is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat[1][2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity[2].
D-Mannose isomerase is a carbohydrate isomerase catalyzing the reversible isomerization of d-mannose to d-fructose. D-Mannose isomerase belongs to the N-acylglucosamine 2-epimerase (AGE) superfamily along with AGE, cellobiose 2-epimerase (CE), and aldose-ketose isomerase (AKI)[1].
Jasminoside B is a natural compound isolated from the rhizomes of Asarum sieboldii with immunosuppressive activity[1].
Sephadex G 200 is a hydrophilic gel that can be used as a gel filter filler (Particle size range: 40-120 μm; Sphere protein separation range: 5k-600k Da)[1].
Beacon (47-73) is a C-terminal peptide fragment 47-73 of Beacon, and Beacon is a protein of 73 amino acid. Beacon (47-73) can be used for metabolic syndrome research[1][2].
STM2120 is a METTL3-METTL14 inhibitor with an IC50 of 64.5 μM[1].
p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) is an organic compound containing amine and aldehyde moieties which is used in Ehrlich's reagent and Kovac's reagent to test for indoles[1].
Diosbulbin B is a diterpene lactone isolated from D. bulbifera L., with anti-tumor activity. Diosbulbin B can induce liver injury[1][2].
Sterigmatocystine, a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor, has developmental, teratogenic, and carcinogenic effects in animals[1][2][3].
Gliquidone (AR-DF 26) is an anti-diabetic drug in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
Delphinidin 3-diglucoside (Delphinidol 3-sophoroside) is a phenolic compound that can be isolated from Punica granatum[1].
Aluminum Glycinate, an organo-metallic compound, is an antacid. Aluminum Glycinate can be used for the research of indigestion, acid reflux and ulcers[1].
(R)-2,4-diamino-4-oxobutanoic acid hydrate is an asparagine derivative[1].
Neurogranin 28-43 is a biological active peptide. (selective PKC substrate)
TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases[1][2]. TMPD dihydrochloride is also a complex IV substrate[3].
Guignardone J is the secondary metabolite isolated from endophytic fungus Phyllosticta capitalensis[1].
Borofalan can be used for Boron neutron capture therapy (BNCT). Borofalan can be used for the research of recurrent or locally advanced head and neck cancer[1].
Pancreastatin (33-49), porcine is a pancreastatin fragment. Pancreastatin is a peptide isolated from porcine pancreas which has insulin-suppressive actions in vitro. Pancreastatin (33-49), porcine enhances the priming effect of glucose[1][2].
Phaseollin is an isoflavonoid phytoalexin that can be isolated from Phaseolus vulgaris . Phaseollin is toxic to bean hypocotyl and endocarp cells, and causes a complete lysis of sheep erythrocytes[1].
Fmoc-Asp(OtBu)-Osu is an aspartic acid derivative[1].
H-Pro-Phe-Thr-Arg-Asn-Tyr-Tyr-Val-Arg-Ala-Val-Leu-His-Leu-OH is an peptide. H-Pro-Phe-Thr-Arg-Asn-Tyr-Tyr-Val-Arg-Ala-Val-Leu-His-Leu-OH can be used for the research of various biochemical studies[1].
Itch-Targeting Compound 1 is an anti-itching agent.
TAT-JIP inhibits the phosphorylation of endogenous c-jun activated by PHA–PMA[1].
Calceolarioside B is a natural product isolated from Stauntonia hexaphylla leaves. Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC50 of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC50 of 94.60 μM [1].
ITIC, non-fullerene acceptor, is an indacenodithienothiophene-based postfullerene electron acceptor, crystallizes in a profoundly different way as compared to fullerenes.ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C.