Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial therapy for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
N-(tert-Butoxycarbonyl)-N-methyl-D-leucine is a leucine derivative[1].
Trisodium nitrilotriacetate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
2-(2-(2-Amino-4-methylpentanamido)acetamido)acetic acid is a Glycine (HY-Y0966) derivative[1].
ELDKWA is the highly conserved amino acids on the ecto-domain of gp41. ELDKWA acts as the epitope of a neutralizing monoclonal antibody 2F5 (mAb 2F5)directed against human immunodeficiency virus type 1[1][2].
Benzoate-d5 (sodium) is the deuterium labeled Sodium benzoate[1].
Dansylcadaverine is a fluorescent probe.
IR 813 tosylate is a near-infrared (NIR) fluorescent dye (λex=815 nm, λem=840 nm) and can be used for visualizing regional lymph nodes in mice[1].
N,N,N-Trimethylbenzenaminium bromide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Regaloside K (Compd 1) is a natural compound that can be isolated from Easter Lily (Lilium longiflorum Thunb.)[1].
Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring. Tartrazine is water-soluble and has a maximum absorbance in an aqueous solution at 425 nm.
Volvalerenic acid A is a germacrane-type sesquiterpenoid that can be found in the roots of Valeriana officinalis var. latifolia[1].
MPS-Gαi3 is a cell penetrating peptide that can be used for drug delivery[1].
1-Adamantanol-d15 is the deuterium labeled 1-Adamantanol[1].
Ligupurpuroside B is a glycoside isolated from Ligustrum robustum, with antioxidant activity[1].
Hel 13-5 is a monomeric synthetic peptide based on the N-terminal segment of human SP-B. Hel 13-5 mainly is a-helical and consists of 13 hydrophobic and 5 hydrophilic amino acid residues. Hel 13-5 can be used in combination with phospholipids for developing pulmonary surfactant model systems[1][2].
Isobutyl decanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
ATTO 565 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 NHS ester is an NHS ester derivative of ATTO 565 that can be used to label proteins or antibodies.
cis-9,10-Methyleneoctadecanoic acid is a cyclopropane fatty acid that has been found in bacteria and in the digestive glands of P. globosa. It is a component of the cell membrane of Staphylococcus aureus, and levels were reduced after treatment with carvacrol. cis-9,10-Methyleneoctadecanoic acid is secreted by H. pylori and enhances histamine- and dibutyryl cAMP-stimulated acid secretion in isolated guinea pig parietal cells. It also activates protein kinase C (PKC) in a calcium-dependent manner.
DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET[1][2].
Gingerglycolipid A is a monoacyldigalactosyl glycerol[1].
Bis(4-chlorophenyl-2,3,5,6)methyl Alcohol-d4 is the deuterium labeled Bis(4-chlorophenyl)methanol Alcohol[1].
(S)-1-(6-amino-9H-purin-9-yl)propan-2-ol-d6 is the deuterium labeled (S)-1-(6-amino-9H-purin-9-yl)propan-2-ol? (Tenofovir Impurity）[1].
KRPpSQRHGSKY-NH2 is a biological active peptide. (This is a phosphorylated PKC substrate peptide)
L-Isoleucine is one of 20 proteinogenic amino acids. L-Isoleucine is an essential amino acid.
N-[(1,1-Dimethylethoxy)carbonyl]thio-L-phenylalanylglycine is a derivative of phenylalanylglycine, can be used in the synthesis of compounds[1].
Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties[1].
N-Methylformamide-d3 is the deuterium labeled N-Methylformamide[1].
Cetirizine Impurity B dihydrochloride is an impurity of Cetirizine dihydrochloride. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
Lyso GB3-d7 is deuterium labeled Lyso GB3.