Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases.Target: OthersAmifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is increased. Ca2+ channels can then be open for a longer time and allow greater acetylcholine release to stimulate muscle at the end plate. A 2005 systematic review from the Cochrane Collaboration found some data favouring its use in LEMS. Amifampridine is also used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. From Wikipedia.
(-)-Isocorypalmine, an alkaloid isolated from Corydalis chaerophylla, possesses antifungal activity[1].
Neotame is a derivative of Aspartame and is a low-caloric and high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame is a non-nutritive sweetener and flavor enhancer that can be used in a variety of foods[1][2].
Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen[1][2].
Polydextrose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
(R)-3-Amino-4-hydroxybutanoic acid is a serine derivative[1].
(S)-2-Methylpyrrolidine-2-carboxylic acid is a proline derivative[1].
1,1,3-Tribromo-3-chloroacetone is a halogenated ozone-chlorine and ozone chloramine disinfection byproducts (DBPs) at elevated bromide levels when chlorine or chloramine is used as a secondary disinfectant[1].
Cyanine5 NHS ester chloride is a red emitting fluorescent dye for labeling of amino-groups in peptides, proteins, and oligonucleotides[1].
Rhodamine 700, a Lambdachrome laser dye, is one of the few rhodamine dyes with near infrared fluorescence and can also be used for mitochondrial staining[1].
Camelliaside A is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace[1].
LDN-27219 is a potent inhibitor of hTGase(Tissue transglutaminase) with an IC50 of 0.6 uM.IC50 value: 0.6 uM [1]Target: hTGase inhibitorLDN-27219 is a potent inhibitor of the enzyme(hTGase), producing 100% inhibition at the screening concentration of 10 uM. To examine the enzyme selectivity of LDN-27219, it was tested as an inhibitor of coagulation Factor XIIIa and caspase 3. At concentrations as high as 50 íM, the compound had no effect on the activities of either of these enzymes. LDN-27219 was found to be nontoxic at concentrations as high as 100 íM in an assay that measures the viability of HT1080 cells, a fibrosarcoma tumor cell line.
Fluorescent brightener 24 is a fluorescent brightening agent of a stilbene type[1].
Tetrabutylammonium acetate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
12α-Hydroxygrandiflorenic acid is a compound isolated from the whole plant of Wedelia chinensis (Osbeck.)[1].
E3 ligase Ligand 4 is a ligand of E3 ligase, used in PROTAC technology.
Glycerol kinase (GyK) is a bacterial sugar kinase, is often used in biochemical studies. Glycerol kinase catalyzes the first step of glycerol metabolism by transforming the triol into glycerol-3-P (G3P). Glycerol kinase is crucial for regulating channel/facilitator-independent uptake of glycerol into the cell[1].
L-Ethionine (L-ETH) is aamino acids and their derivatives.
AEOL-10150 pentachloride is a metalloporphyrin catalytic antioxidant and is a superoxide dismutase mimetic, and protects lungs from radiation-induced injury[1].
Trifluralin is a commonly used pre-emergence herbicide. Trifluralin is generally applied to the soil to provide control of a variety of annual grass and broadleaf weed species. It inhibits root development by interrupting mitosis, and thus can control weeds as they germinate.
Triphenyltin chloride-d15 is the deuterium labeled Triphenyltin chloride[1].
CER11-2’R-d9 is deuterium labeled CER11-2’R.
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium[1].
Diisohexyl phthalate is a class of dialkyl phthalate esters and a plasticizer[1][2].
Aspercolorin, a secondary metabolite, is a cyclic peptide[1].
Fmoc-Phe-OPfp is a phenylalanine derivative[1].
Ethyl (4-cyanophenyl)glycinate is a Glycine (HY-Y0966) derivative[1].
2-Amino-3,7-dihydro-5-iodo-7-β-D-ribofuranosyl-4H-pyrrolo[2,3-d]pyrimidin-4-one is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
3-Pyridine-2,4,5,6-d4 -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester[1].