Tepoditamab (MCLA-117) is a bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab (MCLA-117) kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells and can be used in acute myeloid leukaemia (AML) research[1].
Syringetin-3-O-rutinoside is an antioxidant compound[1]. Syringetin-3-O-rutinoside can be used for the synthesis of syringetin-O-glycoside derivatives[2].
Erteberel (LY500307) is a potent and selective estrogen receptor beta (ERβ) inhibitor with Ki and EC50 of 1.54 nM and 3.61 nM, respectively[1]. Anti-tumor activities[2].
NAAA-IN-3 (Compound 17a) is a potent and selective inhibitor of NAAA with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). NAAA-IN-3 has the potential for the research of inflammation and pain[1].
Quercetin 3-beta-sophoroside is isolated from the flowers of A. venetum, is an scavengers of superoxide anions[1].
((3-Fluorophenyl)sulfonyl)glycine is a Glycine (HY-Y0966) derivative[1].
Monoethyl phthalate-d4 is the deuterium labeled Monoethyl phthalate[1]. Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule[2][3].
Crocetin (β-Crocetin), isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity[1][2].
Platycodin D2 is a saponin isolated from Platycodon grandiflorum, with anti-cancer activity[1].
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3].
DNP-DL-methionine sulfone is a Methionine (HY-13694) derivative[1].
(R)-2,3-Dihydroxypropanal-d4 is the deuterium labeled (R)-2,3-Dihydroxypropanal[1].
N-(4-Aminobenzoyl)-beta-alanine is an alanine derivative[1].
Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle[1].
D 131 is an orange organic indoline dye. The absorption maxima of D131 in solution is λ=425 nm[1][2].
Tetradecyl sulfate sodium, a detergent sclerosant, is widely used agent for esophageal varices and varicose veins[1].
Chromogranin A (324-337), human is a peptide fragment of chromogranin A, it can be isolated from human ileal carcinoid tumor. Chromogranin A is a soluble glycoprotein stored with hormones and neuropeptides in secretory granules of most (neuro)endocrine cells and neurons, and it is also a plasma marker of neuroendocrine tumors[1][2].
Cycloheterophyllin is a flavonoid, that can be isolated from Artocarpus communis and A. heterophyllus. Cycloheterophyllin shows antiinflammatory activity[1].
Fmoc-Pro-Pro-OH is a proline derivative[1].
[Tyr0] Thymus Factor is a polypeptide with 10 amino acids[1].
3-Butenoic acid (Vinylacetic acid) can be used to synthesize bicyclic 3,6-dihydro-1,2-oxazine. Strained bicyclic 3,6-dihydro-1,2-oxazine is a reactive substrate in domino metathesis with an external alkene[1][2].
Stanolone benzoate (Androstanolone benzoate) is a synthetic androgen and anabolic steroid[1].
Nigracin (Poliothyrsoside) is a phenolic glycoside compound with a wound healing activity[1].
4-(Azidomethyl)benzoic acid is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity[1].
AA-dUTP sodium salt is a fluorescent dye which can be used to stain cDNA.
(R)-Thiazolidine-4-carboxylic acid is a proline derivative[1].
Evuzamitide is a diagnostic imaging agent. Evuzamitide as a pan-amyloid radiotracer binding to amyloid deposits from multiple amyloidogenic proteins. Evuzamitide can be used for the research of early diagnosis of amyloid cardiomyopathy (CMP) and monitoring[1][2].
Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase[1].
3-(4-Hydroxybenzylidene)-5-hydroxy-7-methoxychroman-4-one is derived from natural Scilla nervosa subsp. rigidifolia ofisoflavone compounds [1].