Orcinol (3,5-Dihydroxytoluene) is an organic compound used as biological dye and indicator for proteomics research.
3′,4′,7-Trihydroxyflavone is a flavonoid aglycon compound isolated from broad bean pods[1].
S-(3)-Hydroxymyristic Acid, Methyl Ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
2-(2-Ethoxyethoxy)ethanol-d5 is the deuterium labeled 2-(2-Ethoxyethoxy)ethanol[1].
8-Demethoxycephatonine is an isoquinoline alkaloid, that can be isolated from Sinomenium acutum (Menispermaceae)[1].
Vitamin B5-13C3,15N (hemicalcium hemihydrate) is the deuterium labeled Vitamin B5 (hemicalcium hemihydrate)[1].
Benzyl 4-hydroxybenzoate is a prominent material. Benzyl 4-hydroxybenzoate can be used as an excipient, such as bacteriostatic agent, preservative. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
2-Methylcyclopentane-1,3-dione is a key intermediate for the total synthesis of steroids[1].
DACM (N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide) is a thiol-directed fluorescent dye (Ex=396 nm, Em=468 nm)[1].
(R)-3-Aminopiperidine-2,6-dione-d hydrochloride is the deuterium labeled (R)-3-Aminopiperidine-2,6-dione hydrochloride[1].
LCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family, as well as Btk and Syk; potently inhibits the activated tyrosine kinase activity of DDR2 (IC50=6 nM), and nonactivated form of DDR2 (IC50=145 nM); suppresses collagen-induced autophosphorylation of DDR1 and DDR2 with IC50 of 164 and 171 nM in cell-based assays; inhibits all eight Src family kinases with IC50 of 2-20 nM; suppresses the proliferation and migration of primary dermal fibroblasts induced by TGF β1 and type I collagen (IC50=194 nM), inhibits cell migration and nitric oxide, iNOS, COX2, and TNF-α synthesis in LPS-activated J774A.1 macrophage cells; suppresses hypertrophic scar formation in wound healing models.
6-(Methylthio)purine-d3-1 is the deuterium labeled 6-(Methylthio)purine[1].
1LNP Lipid-7 (Compound 7013) is a lipid. LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP) and for drug delivery[1].
H-DL-Phe-OMe.HCl is an alanine derivative[1].
5-Methoxycarbonylmethyl-2'-O-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1].
LL-37 SKE is an active fragment of LL-37[1].
Goshuyuamide-I (compound 4) is a kind of alkaloid. Goshuyuamide-I can be isolated from the fruits of Euodia rutaecarpa. Goshuyuamide-I can be used in the research of analgesics[1].
Albendazole-2-Aminosulfone-d3 (hydrochloride) is the deuterium labeled Albendazole-2-Aminosulfone (hydrochloride).
Hexadecane-1-thiol-d33 is the deuterium labeled Hexadecane-1-thiol[1].
VU0531245 is a SLACK channel inhibitor (IC50: 2.1 μM)[1].
Isohemiphloin is a flavonoid compound[1].
SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.
Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects. IC50 value:Target:In vitro:In vivo: Notoginsenoside R1 significantly reduce blood pressure in spontaneously hypertensive rats and induce nitric oxide generation through increasing the phosphorylation of iNOS. Notoginsenoside R1 reduces the caudal blood pressure of spontaneously hypertensive rats through induction of iNOS regulated by long non-coding RNA AK094457 [1]. The mice with notoginsenoside R1 treatment showed significant amelioration in the cognitive function and increased choline acetyl transferase expression, as compared to the vehicle treated mice. Notoginsenoside R1 treatment inhibited Aβ accumulation and increased insulin degrading enzyme expression in both APP/PS1 mice and N2a-APP695sw cells [2]. In Notoginsenoside R1 treated rats, expression of TGF-β1and Smad3 at each time point was down-regulated, with statistical significance(P0.05) compared with that in the NDMA group [3].
Aurantio-obtusin β-D-glucoside (Glucoaurantio-obtusin), isolated from Cassiae Semen (seeds of Cassia tora), is a glucoside of aurantio-obtusin[1].
(+)-proto-Quercitol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Sarmenoside II is a flavonol glycoside with activity that inhibits lipid accumulation. Sarmenoside II inhibits albumin-oleate-induced lipid accumulation in HepG2 cells by approximately 30% at 100 μM.
4-Fluoro-DL-glutamic acid is a glutamic acid derivative[1].
4-Azido-L-phenylalanine is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments.
Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.
6''-Acetylhyperin is a natural phenolic compounds that could be found in Nymphaea odorata[1].