Ro18-5362 is the less active prodrug of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation.
L-Lysine thioctate is a substrate of lipoamidase[1].
S07-2005 racemic is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. S07-2005 racemic has potential as a chemotherapeutic potentiator for cancer drug resistance[1].
L-Lysine ethyl ester dihydrochloride is a lysine derivative[1].
Z-β-D-HomoAla-OH is an alanine derivative[1].
4-Fluorobenzonitrile-d4 is the deuterium labeled 4-Fluorobenzonitrile[1].
Diflumidone is a non-steroidal antiinflammatory drug.
Fmoc-D-Phe(4-I)-OH is a phenylalanine derivative[1].
MDH1-IN-1 (Compound 5i) is a potent inhibitor of MDH1 with an IC50 of 6.79 μM. MDH1-IN-1 has the potential for the research of cancer diseases[1].
Maoecrystal B is a diterpenoids compound isolated from the leaves of Isodon eriocalyx var. laxiflora[1].
2-Amino-2-(thiophen-3-yl)acetic acid is a Glycine (HY-Y0966) derivative[1].
Dihydromicromelin B is a natural product that can be isolated from the leaves of Micromelum integerrimum[1].
N-Trityl-L-serine lactone is a serine derivative[1].
Protopine, an isoquinoline alkaloid contained in plants in northeast Asia.IC50 Value:Target:In vitro: Protopine was found to reduce nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E(2) (PGE(2)) production by LPS-stimulated Raw 264.7 cells, without a cytotoxic effect. Pre-treatment of Raw 264.7 cells with protopine reduced the production of pro-inflammatory cytokines [2]. Protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins [3]. In HepG2 cells, protopine significantly increased CYP1A1 mRNA levels after 24h exposure at concentrations from 25 and 10 μM. Protopine also dose-dependently increased CYP1A1 and CYP1A2 mRNA levels in human hepatocytes [4].In vivo: Assays were performed on MDA-MB-231 human breast cancer cells, and the result showed that protopine exhibited anti-adhesive and anti-invasion effects in MDA-MB-231 cells; after treatment with protopine for 90 min, the expression of EGFR, ICAM-1, αv-integrin, β1-integrin and β5-integrin were remarkably reduced [1].
Fmoc-Ile-OH is an isoleucine derivative[1].
5,6,7,40-Tetrahydroxyisoflavone-6,7-di-o-b-D-glucopyranoside is an isoflavonoid glycoside isolated from Pueraria lobata[1].
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].
TFAX 488,TFP, an amine reactive green fluorescent dye, is insensitive to pH in the range 4-10. TFAX 488,TFP forms bright and photostable conjugates with proteins and antibodies. TFAX 488,TFP is less susceptible to spontaneous hydrolysis during conjugation reactions compared to SE or NHS dyes. TFAX 488,TFP also displays greater stability compared to NHS and SE versions, typically lasting several hours. TFAX 488,TFP is suitable for use in flow cytometry, two-photon excitation microscopy (TPE), and super resolution microscopy techniques, such as dSTORM, SIM and STED. Excitation maximum=495 nm; emission maximum=515 nm; extinction coefficient=73,000 M-1cm-1; quantum yield=0.92.
DL-3-Phenylalanine is a phenylalanine derivative[1].
Kaolin can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model[1].
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells[1].
Microtubule-Associated Protein (142-161) (human) is a biologically active peptide.
Cubebin is a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo. Cubebin shows a significant anti-inflammatory activity[1].
Fmoc-D-4-Pal-OH is an alanine derivative[1].
Abscisic acid ((S)-(+)-Abscisic acid) is a plant hormone which is as a growth inhibitor. Abscisic acid has been shown to regulate many aspects of plant growth and development including embryo maturation, seed dormancy, germination, cell division and elongation, floral induction, and responses to environmental stresses such as drought, salinity, cold, pathogen attack and UV radiation[1].
PSX020 is the hosta plantaginea flower extract with antioxidant effects[1].
Phenolphthalein is a widely applied but toxic indicator dye.
Fmoc-Cys(Acm)-OH is a cysteine derivative[1].
Ac-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2 is a peptide, can be used to synthesise tyrosine kinase inhibitor for hair growth reduction[1].