Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity[1][2].
A benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13); show highly potent in vitro bactericidal activity against drug-susceptible and drug-resistant clinical isolates of M. tuberculosis (MICs: 0.06-0.25 uM); exhibits in vivo efficacy in multiple mouse models of TB infection, has excellent pharmacological and safety profiles.
CBS1117 is a virus entry inhibitor with an IC50 of 70 nM for influenza A viruses, A/Puerto Rico/8/34 (H1N1). CBS1117 interferes with the hemagglutinin (HA)-mediated fusion process[1].
Peramivir (RWJ 270201; Rapiacta; BCX 1812) is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.IC50 Value: 0.09 nMTarget: NeuraminidasePeramivir is an experimental antiviral drug developed by BioCryst Pharmaceuticals for the treatment of influenza. It has been authorized for the emergency use of treatment of certain hospitalized patients with known or suspected 2009 H1N1 influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. From Wikipedia
5-Hydroxysophoranone is a flavanone that can be isolated from the Erythrina subumbrans. 5-Hydroxysophoranone shows weak antibacterial activity against several strains of Streptococcus[1].
Phenethicillin (α-Phenoxyethylpenicillin) sodium is a Penicillin, and has antimicrobial activity[1].
HIV-1 capsid inhibitor 1 is a potent HIV-1 Capsid inhibitor with an EC50 value of 3.13 µM. HIV-1 capsid inhibitor 1 shows antiviral activities[1].
Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis[1].
ASP5286 is a novel non-immunosuppressive cyclophilin inhibitor for the treatment of HCV.
trans-β-terpineol, a monoterpenoid compound, can be isolated from the leaves of Schinus terebinthifolius. Terpineol has antioxidant and antibacterial activity. trans-β-terpineol is a bioactive compound that plays an antibacterial role in Schinus terebinthifolius[1].
Rosoxacin (Acrosoxacin) is a potent and orally active quinolone antibiotic. Rosoxacin (Acrosoxacin) has antibacterial activities against a broad spectrum of Gram negative bacteria including Neisseria gonorrhoeae (MIC90=0.03mg/ml). Rosoxacin has the potential for urinary tract infections treatment[1].
Cefodizime sodium is a third generation cephalosporin with a broad spectrum of antibacterial activity[1]. Cefodizime sodium has some peculiar merits such as no renal toxic effect, good tolerance and even the activity of immune regulation，and is widely used in the treatment of severe infections of the respiratory and urinary tracts[2].
Ochratoxin C is the ethyl ester analog of ochratoxin A, a mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant. Ochratoxin C rarely occurs as an initial natural contaminant due to a transformation from ochratoxin A.
Semzuvolimab is a murine IgG1κ antibody, targeting to p55, T cell surface antigen T4/Leu-3 (CD4). Murine CD4 antibodies can neutralize HIV infection and have the potential to inhibit HAART stable HIV infection[1][2].
Sofosbuvir (PSI-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM.
Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.IC50 Value: Target: HCV NS3/4A Protease; HCVvaniprevir (MK-7009) is a macrocyclic hepatitis C virus NS3/4a protease inhibitor, is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir (MK-7009) has good plasma exposure and excellent liver exposure in multiple species.
Artefenomel (OZ439) is a synthetic antimalarial agent with the artemisinin pharmacophore. Artefenomel (OZ439) is a long-acting artemisinin-related agent[1].
Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1].
CRAMP (mouse) is an antimicrobial peptide. CRAMP (mouse) can be used for the research of biofilm-associated infections[1].
Vasicinolone, a natural alkaloid, exhibits anti-inflammatory and antimicrobial properties[1].
1-Hydroxy-2-methylanthraquinone exhibits antimicrobial, antioxidant, pesticidal, and anti-inflammatory activities[1].
Tylosin (Fradizine; Tylocine; Tylosin A) is a broad spectrum antibiotic against Gram-positive organisms and a limited range of Gram-negative organisms.
RSV-IN-1 is a human respiratory syncytical virus (hRSV) inhibitor, with an IC50 of 0.11 μM.
Pivmecillinam (FL-1039) is an orally active prodrug of mecillinam, an extended-spectrum penicillin antibiotic.
FWM-3 is a potent SARS-CoV-2 NSP13 helicase inhibitor[1].
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].
Erythromycin stearate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin stearate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin stearate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].
BI-2540 is a HIV non-nucleoside reverse transcriptase (NNRT) inhibitor[1][2].
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge[1][2].
α-Lipomycin is an acyclic polyene antibiotic isolated from the gram-positive bacterium Streptomyces aureofaciens Tü117[1].