Glyoxalase I inhibitor 1 (compound 23) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 26 nM[1].
STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer[1].
Ganglioside GM3 sodium salt is a sialylated membrane-based glycosphingolipid that regulates insulin receptor signaling via direct association with the receptor. Ganglioside GM3 sodium salt possesses powerful effects on cancer development and progression[1][2].
Anhydrosafflor yellow B (AHSYB) is a quinochalcone C-glycoside isolated from Carthamus tinctorius. Anhydrosafflor yellow B inhibits ADP-induced platelet aggregation, exhibits significant anti-oxidative effects in vitro, and possesses certain activity against H2O2-induced cytotoxicity in cultured PC12 cells and primary neuronal cells[1].
Mogroside VI A, an isomer of Mogroside VI isolated from Luo Han Guo, exerts sweetness property. Mogroside VI A can be used for sweetener and/or taste modifier research[1].
Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].
N3-TOTA-Suc is a click chemistry reagent containing an azide group. Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments[1].
(R)-1-Benzylpyrrolidine-2-carboxylic acid is a proline derivative[1].
Didecyl phthalate-d4 is the deuterium labeled Didecyl phthalate[1].
7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid[1].
5-Hydroxy Propafenone D5 Hcl is the deuterium labeled 5-Hydroxy Propafenone.
Palustric acid is a diterpenic resin acid found in Pinus nigra[1][2].
Ethyl 2-(benzylamino)acetate is an important chemical, pesticide and pharmaceutical intermediate with a wide range of applications in the synthesis of chemical products[1].
5-IAF is an idoacetamide derivate of fluoresceine.
Rabacfosadine (GS-9219), a novel prodrug of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells.
(±)-Cleroindicin E is a natural compound isolated from the herbs of Clerodendrum indicum[1].
(R)-2-Amino-2-(thiophen-2-yl)acetic acid is a Glycine (HY-Y0966) derivative[1].
MSI-1701 is an analogue of MSI-1436 which can control weight gain and blood glucose level extracted from patent US 7410959 B1.
NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM; decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.); decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD).
Fepixnebart is a humanized IgG4κ antibody targeting TGF-alpha (TGFA).
[Lys0]γ1-MSH is a γ1-melanotropin-like peptide, one of 1600-dalton γ-MSHs. [Lys0]γ1-MSH can be isolated from bovine neurointermediate pituitary lobes[1].
Bivatuzumab (Anti-CD44 Recombinant Antibody; BIWA 4) is a humanized monoclonal antibody directed against CD44v6. CD44v6 could acts as a sarcoma target for CAR-redirected CIK cells[1].
Calf thymus DNA is high quality double-stranded template DNA isolated from the thymus of male and female calves.
H-His(1-Me)-OMe is a histidine derivative that can be used for amino acid synthesis[1].
γ-Lumicolchicine is an inactive analogue of Colchicine (HY-16569)[1]
3',4',5',5,7-Pentamethoxyflavanone is a natural flavonoid compound found in Neoraptua magnifica var. magnifica[1].
DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) , and characterized its activity in ex vivo and in vivo assays of bone resorption[1].
Piperitol is a compound isolated from the Tibetan medicinal plant Lancea tibetica[1].
17α,20β-Dihydroxy-4-pregnen-3-one (17,20β-P) is a maturation-inducing steroid[1].
Kadsuphilin A can be extracted from Kadsura coccinea (Lem.) and has weak antiproliferative activity[1].