Fmoc-Ile-OPfp is an isoleucine derivative[1].
Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML)[1][2].
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with an IC50 of 0.5 μM.
7-O-Methylmangifer is isolated from the cortexes of Polygala tenuifolia[1].
Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release)[1].
Phlorigidoside C, a natural iridoid glucoside, possesses anti-rheumatoid arthritis effect[1].
4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines[1][2].
MCA succinimidyl ester is a derivative of MCA (HY-W027544). MCA succinimidyl ester has succinimidyl ester can react selectively with amines. MCA succinimidyl ester can be used as peptide substrate for fluorescence resonance energy transfer[1].
1,2,3,4-Tetramethylbenzene-d14 is the deuterium labeled 1,2,3,4-Tetramethylbenzene[1].
Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp[1]. Neosolaniol evokes robust anorectic response[2].
CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates[1][2].
Nα-p-Tosyl-L-lysine methyl ester hydrochloride is a lysine derivative[1].
N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λmax=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers[1][2][3].
Trimethylsulfoxonium-d9 Iodide is the deuterium labeled Trimethylsulfoxonium Iodide[1].
P7C3-OMe is a pro-neurogenic compound, has therapeutic benefits in neuropsychiatric and/or neurodegenerative disease. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer[1].
Araloside C exhibits protective effects against myocardial ischaemia/reperfusion injury[1].
Se-DMC attenuates complete Freund’s adjuvant (CFA)-induced inflammatory response, nociception, and neurobehavioral deficits in mice.
4-trans-Hydroxycyclohexylamine (trans-4-Aminocyclohexan-1-ol) is a raw material in organic synthesis[1].
H-D-Phe(2-Cl)-OH is a phenylalanine derivative[1].
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].
Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].
Morusignin L is an active compound that shows anti-osteoporosis activities[1][2].
Jatrophane 2 is a kind of jatrophane diterpene polyester obtained from the highly irritant extract of whole fresh plants of E. peplus L. (Euphorbiaceae)[1].
Blu667 is a highly potent and selective RET inhibitor with an IC50 of 0.4 nM for wild type RET kinase.
Peucedanoside A is a glycoside that can be isolated from the roots of Peucedanum praeruptorum Dunn[1].
3,4-Methylenedioxycinnamic acid is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase. 3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid[1].
Boc-Ala-Ala-OH (NSC 334362) is an Alanine derivative. Boc-Ala-Ala-OH is used in the preparation of anti-bacterial agent[1].
1-Bromo-3,5-dichlorobenzene-d3 is the deuterium labeled 1-Bromo-3,5-dichlorobenzene[1].
N-Benzyl-6-chloropyrimidin-4-amine is a pyrimidine derivative[1].
Triptotriterpenic acid C is a ursolic-type acid that can be isolated from total glycosides extracted from the root of Tripterygium wilfordii Hook.f.[1].