Antiproliferative agent-35 (Compound 4) inhibits the proliferation of B16 and A549 cells, with IC50s of 13.2 and 9.2 μM resspectively[1].
Nagrestipen, a human macrophage inflammatory protein-1 alpha (MIP-1α) variant, also known as ECI 301. Nagrestipen has antitumor activity and can be used in therapeutic trials to study cancer, tumors, metastases, radiation oncology, and tumor metastasis[1].
Insulin β Chain Peptide (15-23), also known as INS, is an insulin-derived peptide recognized by islet-associated T cells. The Insulin β Chain Peptide (15-23) tetramer stained the INS-reactive CTL clone G9C8, but neither this tetramer nor the negative control tetramer (TUM) stained the splenic CD8+ T cells from NOD or 8.3-TCRαβtransgenic NOD mice[1][2].
1-Cyclohexanol-d12 is the deuterium labeled 1-Cyclohexanol[1].
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint[1].
Epifriedelanol is a triterpenoid isolated from the root bark of Ulmus davidiana, with antitumor activity[1]. Epifriedelanol inhibits cellular senescence in human primary cells[2].
Kotanin is a metabolite of Aspergillus glaucus[1].
NSC 1940-d4 is the deuterium labeled NSC 1940[1].
Bexlosteride (LY300502) is a benzoquinolinone human type I 5α-reductase inhibitor. Bexlosteride shows metabolic inhibitory, antiproliferative, and antisecretory effects in LNCaP human prostatic adenocarcinoma cell cultures. Bexlosteride can be used for the research of prostatic cancer[1][2].
H-Met-OtBu.HCl is a Methionine (HY-13694) derivative[1].
(3-Bromopyridin-2-yl)methanol-d2 is the deuterium labeled (3-Bromopyridin-2-yl)methanol[1].
MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM.
Tregalizumab is a humanized anti-human CD4 monoclonal antibody (IgG1 type) that selectively activates the suppressive properties of regulatory T cells (Tregs) in vitro. Tregalizumab can be used in the research of autoimmune diseases (resulting from insufficient Treg activity) and allergies[1][2][3].
Multiflorin A is an active ingredient derived from Pruni semen. Multiflorin A has laxative activity. Multiflorin A inhibits intestinal glucose absorption and promotes bacterial metabolism[1].
Oleoside can be isolated from olive pomace[1].
Dihydralazine sulfate is an antihypertensive agent.
9-Demethyl FR-901235 is the 9-demethyl derivative of immunomodulator FR-901235[1].
(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is an important peptide hormone[1].
Trimethoprim propanoic acid is a hapten.
Hederacoside C is a principal bioactive pharmaceutical ingredient of Hedera helix leaf that can treat respiratory disorders, because of its expectorant, bronchodilator, antibacterial, and bronchospasmolytic effects.
Methoxatin (disodium salt) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy.Target:Methoxatin has been isolated from guinea-pig neutrophils. The presence of Methoxatin in guinea-pig neutrophils and suggest that it has a possible role, direct or indirect, in the O2.(-)-producing respiratory burst.
Cy5-SE (Cy5 NHS Ester) triethylamine salt is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. Cy5-SE triethylamine salt is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides Ex=649 nm; Em=670 nm)[1].
L-Leucine β-naphthylamide (hydrochloride) is a leucine derivative[1].
Imidazole is a planar 5-membered ring. Imidazole is a highly polar compound. Imidazole has been used extensively as a corrosion inhibitor.Imidazole is incorporated into many important biological molecules. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Imidazole is useful as a buffer in the pH range of 6.2-7.8 One of the applications of imidazole is in the purification of His-tagged proteins in immobilised metal affinity chromatography(IMAC). Imidazole is used to elute tagged proteins bound to Ni ions attached to the surface of beads in the chromatography column. An excess of imidazole is passed through the column, which displaces the His-tag from nickel co-ordination, freeing the His-tagged proteins. Imidazole has become an important part of many pharmaceuticals. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, which stimulates the central nervous system. It is present in the anticancer medication mercaptopurine, which combats leukemia by interfering with DNA activities.
26Rfa, Hypothalamic Peptide, human is a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity[1]. 26RFa is an orexigenic neuropeptide identified as the endogenous ligand of the orphan G protein-coupled receptor GPR103[2].
Volemitol (D-Volemitol) is a seven-carbon sugar alcohol that fulfills several important physiological functions in certain species of the genus Primula. Volemitol is the major nonstructural carbohydrate in leaves of all stages of development. Volemitol functions as a photosynthetic product, phloem translocate (phloem-mobile), and storage carbohydrate.Volemitol biosynthesis proceeds by a novel, NADPH-dependent, ketose reductase (sedoheptulose reductase)[1].
Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity[1].
2-(Dimethylamino)acetaldehyde hydrochloride can be used to synthesis Muscarine analogues[1].
(3β,20E)-24-Norchola-5,20(22)-diene-3,23-diol is a steroid-based allylic alcohol.
Sodium Nitroprusside is a potent vasodilator working through releasing NO spontaneously in blood.Target: OthersSodium Nitroprusside is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium Nitroprusside breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate [1]. Sodium nitroprusside decreases the proliferation of vascular smooth muscle cells [2]. Sodium nitroprusside (5 mg/kg) significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats [3].