6-(1-Piperazinyl)-9-β-D-ribofuranosyl-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Saxagliptin-15N,d2 (hydrochloride) is the deuterium and 15N labeled Saxagliptin[1].
Nile Blue A perchlorate is a laser dye used for pulsed and CW operations.
M40 is a potent, non-selective galanin receptor antagonist.
trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated linoleic acid (CLA) at the tissue level.
(R)-Fmoc-4-(3-pyridyl)-β-Homoala-OH is an alanine derivative[1].
1-Bromo-4-phenoxybenzene-d5 is the deuterium labeled 1-Bromo-4-phenoxybenzene[1].
Trans-2-octen-1-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite[1].
Pyrene is polycyclic aromatic hydrocarbon which is well-known for its ability to intercalate into DNA. Pyrene features intense blue fluorescence. Its parameters depend strongly on fluorophore microenvironment. Therefore, fluorescence spectra of pyrene are used for the extraction of structural information about site surrounding pyrene. Two pyrenes in close proximity usually form excimers easily detectable by excimer fluorescence. Pyrene can also be a FRET donor to other fluorophores such as perylene.
1,2,4,6-Tetra-O-acetyl-3-O-allyl-β-D-glucopyranose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Pulsatilloside E (Chinensioside B) is a triterpenoidal saponin isolated from the roots of Pulsatilla chinensis (Ranunculaceae)[1].
4-Maleimidosalicylic acid is a polar maleimide, and does not suppress IL-2 production in JURKAT T cells[1].
Methyl β-D-glucopyranoside (Methyl β-D-glucoside) hemihydrate is a hemihydrate compound. Methyl β-D-glucopyranoside hemihydrate less reactive at higher PH. The formation of Methyl β-D-glucopyranoside hemihydrate is stereospecific[1][2].
C12-iE-DAP (Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid) is a biological active peptide. (a lauroyl (C12) group to the glutamic residue of iE-DAP , NOD1 agonist)
Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.Target: carbonic anhydrase (CA)Dorzolamide hydrochloride is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour [1]. Glaucoma was induced in the right eye of adult Wistar rats by episcleral venous occlusion. One experimental group was administered dorzolamide hydrochloride 2%-timolol 0.5% combination eye drops, while the other experimental group was administered dorzolamide hydrochloride2% eye drops. Control groups had surgery without drug administration. Drug application was initiated either 2 weeks before surgery (Group A), from the day of surgery (Group B), 2 weeks after surgery (Group C), or 4 weeks after surgery (Group D). RGCs were labeled by intratectal Fluorogold injections and counted from flat-mount preparations, and IOP was measured using Tonopen. Both dorzolamide-timolol combination and dorzolamide hydrochloride, when applied topically, significantly reduced IOP and improved RGC densities in experimental eyes when compared to control eyes. Earlier initiation, as well as longer duration of drug application, resulted in higher RGC densities [2].Clinical indications: Glaucoma; Ocular hypertensionFDA Approved Date: 1995Toxicity: Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest
Caramel is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis[1][2].
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
N-Acetylglycine is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
SAP1 is a biological active peptide. (inhibited virus entry into the cells)
Boc-2-Nal-OH is an alanine derivative[1].
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 (IC50 = 5 nM).
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5[1][2][3].
N-(2-Aminoethyl)-N-benzylglycine Bis trifluoroacetate is a peptide, it can be used to synthesize compounds[1].
Octan-2-yl 2-cyanoacrylate is a cyanoacrylate compound widely used in industry and medicine as a fast-curing glue or tissue adhesive[1].
Methyl 13-Methyltetradecanoate is a methylated bacterial fatty acid methyl ester. By GC-MS, it has been used as a marker of bacteria in sewage sludge and bacterial contamination in pharmaceutical manufacturing.
BMS-986278 is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist, with a human LPA1 Kb of 6.9 nM.
DBCO-PEG2-NHS ester is a click chemistry reagent containing an azide group. DBCO-PEG2-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only[1].