Guanidinosuccinic acid is a nitrogenous metabolite isolated in excess from serum and urine.
Ibuproxam (G 277) is a non-steroidal anti-inflammatory agent[1].
PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].
TNH is a dimer that can enter living cells and recruit proteins into cellular structures[1].
H-Met-Arg-OH is a biologically active peptide.
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2].
Yadanzioside F is one of the toxic components found in Brucea javanica[1]. Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties[2].
HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. HA15 exhibits strong efficacy in melanoma cells. The 50% inhibitory concentration (IC50) in A375 cells was between 1 and 2.5 mM HA15. [1]In vivo: HA15 induces ER stress leading to cancer cell death. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cellseither sensitive or resistant to BRAF inhibitors. [1]
GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
Cantleyoside is a natiural iridoid glycoside that could be found in the Roots of Dipsacus asper[1].
Boc-His(Tos)-OH is a histidine derivative[1].
Microcystin-LW is a bacterial metabolite. Microcystin-LW is an analog of microcystin-LR. Microcystin-LW has cellular toxicity[1][2].
Serratenediol (Cathaya D) is a triterpenoid isolated from Pinus banksiana Lamb[1].
2′,7′-Dichlorofluorescein diacetate (DCFH-DA) is a cell-permeable fluorescent probe. 2′,7′-Dichlorofluorescein diacetate can be used to detect the generation of reactive oxygen intermediates and for assessing the overall oxidative stress in toxicological phenomenon[1].
L-Aspartic acid β-hydroxamate is an aspartic acid derivative[1].
Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent[1][2].
N,N′-Dibenzoyl-L-cystine is a cysteine derivative[1].
trans-N-Methyl-4-methoxyproline is a natural product that can be isolated from the stems of Petiveria alliacea and is also a Proline derivative[1].
Gly-Asp is a Glycine (HY-Y0966) derivative[1].
Methylisopelletierine is the immediate precursor of psueudopelletierine. Methylisopelletierine is derived from lysine and acetate[1].
3-Iodothyronamine (hydrochloride) is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure[1].
5α-reductase-IN-1 is an inhibitor of 5α-reductase, used for the research of patterned alopecia in combination with minoxidil.
D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs[1][2].
Quercetin-3-O-D-glucosyl]-(1-2)-L-rhamnoside is main antioxidant from Shuxuening, an herbal medicines injection[1].
Magnocurarine a natural compound isolated from Tiliacora racemosa[1].
CalFluor 488 Azide is a water-soluble fluorogenic azide probe. CalFluor 488 Azide is activated by Cu-catalyzed or metal-free click reaction. CalFluor 488 Azide is not fluorescent until it is reacted with alkynes[1][2].
Macropa-NH2, a H2macropa derivative with an macrocyclic core of macropa, can be used in targeted cancer therapy research[1].
Cyclohexyl [3,5-bis(methylthio)-4-isothiazolyl]carbamate is a compound that can be used for altering the lifespan of eukaryotic organisms[1].
Gal-C4-Chol is a glycosylated cholesterol derivative. Gal-C4-Chol can be used as a ligand for asialoglycoprotein receptors (ASGPR) to prepare Galactosylated (Gal) liposomes. Gal-C4-Chol can be used to prepare simple lipid-based nanoparticles[1][2][3].
Calystegine A3 is a natural product that can be isolated from Calystegia sepium[1].